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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (05): 698-701. 上一篇    下一篇

研究简报

在离子液体中4-芳基-5-氧代-1,4,5,6,7,8-六氢喹啉-3-羧酸酯的合成

杜百祥，李玉玲，王香善*， 张梅梅，史达清，屠树江   

  1. (徐州师范大学化学系 江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2005-07-11 修回日期:2005-11-04 发布日期:2006-04-28
  • 通讯作者: 杨光富

Synthesis of 4-Aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate in Ionic Liquid

DU Bai-Xiang,LI Yu-Ling,WANG Xiang-Shan*,ZHANG Mei-Mei
SHI Da-Qing,TU Shu-Jiang   

  1. (Department of Chemistry, Xuzhou Normal University, The Key Laboratory of Biotechnology on
    Medical Plant of Jiangsu Province, Xuzhou 221116)
  • Received:2005-07-11 Revised:2005-11-04 Published:2006-04-28
  • Contact: YANG Guang-Fu

PDF

907

被引次数

12

以芳醛、氨基巴豆酸酯和5,5-二甲基-1,3-环己二酮或1,3-环己二酮为原料在离子液体[bmimBF4]中合成了一系列4-芳基-5-氧代-1,4,5,6,7,8-六氢化喹啉-3-羧酸酯, 该方法具有产率高、环境友好等特点. 产物的结构通过红外光谱和核磁共振氢谱进行表征, 并通过X单晶衍射分析进一步证实产物的结构.

关键词: 离子液体, 六氢喹啉, 合成, 绿色化学

4-Aryl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylates were synthesized by the reaction of aromatic aldehydes, 5,5-dimethyl-1,3-cyclohexanedione or 1,3-cyclohexanedione and 2-aminocroto- nate in ionic liquid [bmimBF4]. Compared with the previous methods, this new method has the advantages of high yields and environmental benignity. The structure of products was characterized by IR, 1H NMR spectra and elemental analyses, and further confirmed by X-ray analysis.

Key words: hexahydroquinoline, synthesis, green chemistry, ionic liquid