有机化学 ›› 2006, Vol. 26 ›› Issue (08): 1133-1135. 上一篇    下一篇

研究简报

室温离子液体中CuBr-脯氨酸催化的硫醇、硫酚与卤代芳烃的偶联反应

郑云法1,杜杏芬1,杨明华1,包伟良*,1,2   

  1. (1丽水学院化学系 丽水 323000)
    (2浙江大学西溪校区化学系 杭州 310028)
  • 收稿日期:2005-09-05 修回日期:2006-02-27 发布日期:2006-07-26
  • 通讯作者: 包伟良

CuBr-Catalyzed Coupling Reactions of Aryl Bromide withThiophenol and Thiol Promoted by Proline in Ionic Liquid

ZHENG Yun-Fa1,DU Xing-Fen1,YANG Ming-Hua1,BAO Wei-Liang*,1,2   

  1. (1 Department of Chemistry, Lishui University, Lishui 323000)
    (2 Department of Chemistry, Xixi Campus, Zhejiang Univer-sity, Hangzhou 310028)
  • Received:2005-09-05 Revised:2006-02-27 Published:2006-07-26
  • Contact: BAO Wei-Liang

室温离子液体中, 用脯氨酸为配体, CuBr催化作用下有效地实现了硫醇、硫酚与溴代芳烃的偶联反应. 该反应时间较短, 反应条件温和, 收率高, CuBr-脯氨酸离子液体可以循环使用三次.

关键词: 室温离子液体, 脯氨酸, 不对称芳硫醚, 溴化亚铜

In the presence of proline, the CuBr-catalyzed coupling reaction of thiols with bromoaromatics was conducted at 120 ℃ using ionic liquid [bmim]BF4 as solvent. The experimental results showed that the reaction could be accomplished at shorter time with coupling products in high yields and ionic liquid-CuBr-proline recycled for three times before thorough treatment.

Key words: proline, cuprious bromide, unsymmetrical aryl sulfide, room temperature ionic liquid