关键词: α,β-环氧酮, 超声辐射, 水溶液, 相转移催化, Darzens缩合

Synthesis of 2,3-epoxy-1-phenyl-3-(un)substituted phenyl-1-propanone via Darzens condensation of (un)substituted benzaldehydes with phenacyl chloride was carried out in good yields in the aqueous sodium hydroxide solution under ultrasound irradiation. The combination of phase transfer catalysis and ultrasound irradiation improved the yields. In comparison with the classical methods, this procedure has the advantages of mild conditions, no requirement of toxic solvent, short reaction time and high yields.

Key words: ultrasound irradiation, aqueous media, phase transfer catalysis, Darzens condensation, α,β-epoxy ketone