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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (01): 60-64. 上一篇    下一篇

研究论文

Raney镍催化下生物活性化合物的微波辅助脱硫反应

PANUNZIO, Mauro*,a，BANDINI, Elisab，D'AURIZIO, Anto-niob
MARTELLI, Giorgiob，TAMANINI, Emilianob
肖尚友c，夏之宁*,c   

  1. (a ISOF-CNR Dipartimento di Chimica “G. Ciamician” Via Selmi, 240126 Bologna, Italy)
    (b ISOF-CNR Via Gobetti 101, 40121 Bologna, Italy)
    (c重庆大学化学化工学院药学系 重庆 400044)
  • 收稿日期:2006-11-01 修回日期:1900-01-01 发布日期:2008-01-23
  • 通讯作者: 夏之宁

Microwave-Assisted Desulfurization of Significant Biologically Active Compounds by Raney Nickel

PANUNZIO Mauro*,a, BANDINI Elisab, D'AURIZIO An-toniob, MARTELLI Giorgiob TAMANINI Emili-anob, XIAO Shang-Youc, XIA Zhi-Ning*,c   

  1. (a ISOF-CNR Dipartimento di Chimica “G. Ciamician” Via Selmi, 240126 Bologna, Italy)
  • Received:2006-11-01 Revised:1900-01-01 Published:2008-01-23
  • Contact: XIA Zhi-Ning

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微波辅助脱硫反应具有反应速度快、收率高等优点, 已成为一种有效的脱硫方法, 在生物活性化合物的合成中将得到越来越广泛的应用. 以乙醇为溶剂, 通过微波辅助还原相应苯硫基取代的前体化合物, 制备了一系列具有显著生物活性的化合物.

关键词: 杂环化合物, 脱硫, 微波辅助有机合成, 加巴喷丁, β-内酰胺

Microwave-assisted desulfurization reaction, which has the advantages of fast speed and high yields, has become one of the most efficient desulfurization methods. It will be used more and more extensively in the synthesis of biologically active compounds. In this paper, a series of significant biologically active molecules were prepared by microwave-assisted reduction of the corresponding phenylthio substituted precursors by Raney nickel using ethanol as solvent.

Key words: desulfurization, heterocyclic compound, microwave-assisted organic synthesis, gabapentin, β-lactam