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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (06): 1040-1043. 上一篇    下一篇

研究论文

meso-去甲二氢愈创木酸和Machilin A的合成

夏亚穆*,a，王琦a，丁一宁a，杨丰科a，曹小平b   

  1. (a青岛科技大学化工学院 青岛 266042)
    (b兰州大学化学化工学院 兰州 730000)
  • 收稿日期:2007-09-22 修回日期:2007-11-29 发布日期:2008-06-26
  • 通讯作者: 夏亚穆

Synthesis of meso-Nordihydroguaiaretic Acid and Machilin A

XIA Ya-Mu*,a, WANG Qi a, DIN Yi-Ninga, YANG Feng-Kea, CAO Xiao-Pingb   

  1. (a College of Chemical Engineering, Qingdao University of Science and Technology, Qingdao 266042)
    (b College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000)
  • Received:2007-09-22 Revised:2007-11-29 Published:2008-06-26
  • Contact: XIA Ya-Mu

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报道了一条合成内消旋去甲二氢愈创木酸(meso-NDGA)和Machilin A的新路线. 此路线通过两次Stobbe缩合构建木脂素结构骨架, 经官能团转换, 合成了meso-NDGA和Machilin A. 该路线操作简便、实用性强.

关键词: 去甲二氢愈创木酸, Machilin A, Stobbe缩合

A novel synthetic route to natural nordihydroguaiaretic acid and Machilin A is described. This method involves two Stobbe condensations to give the skeleton of lignan, then fellowed by transformation of functional groups to obtain target compounds. The method operation is convenient and practical.

Key words: Machilin A, Stobbe condensation, nordihydroguaiaretic acid