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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (06): 1035-1039. 上一篇    下一篇

研究论文

5-[2-(8-羟基喹啉-2-基)乙烯基]-2-甲基-8-羟基喹啉的合成、抗氧化活性及促进鼠骨髓间质干细胞增殖的研究

张培全，曾和平*   

  1. (华南理工大学化学科学学院功能分子研究所 广州 510641)
  • 收稿日期:2007-09-11 修回日期:2007-12-07 发布日期:2008-06-26
  • 通讯作者: 曾和平

Synthesis, Antioxidation Activity of 5-[2-(8-Hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol and Its Induction Proliferation ofMesenchymal Stem Cells

ZHANG Pei-Quan, ZENG He-Ping*   

  1. (Institute of Functional Molecules, Faculty of Chemistry, South China University of Technology, Guangzhou 510641)
  • Received:2007-09-11 Revised:2007-12-07 Published:2008-06-26
  • Contact: ZENG He-Ping

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711

被引次数

9

设计合成了5-[2-(8-羟基喹啉-2-基)乙烯基]-2-甲基-8-羟基喹啉(5), 用IR, UV, 1H NMR, MS和元素分析确认其结构. 利用DPPH•法和噻唑蓝比色法(MTT法)分别测定了目标产物的抗氧化活性及调控鼠骨髓间质干细胞(MSCs)增殖的作用. 结果表明, 目标产物有较强的抗氧化活性, 在低浓度时对鼠骨髓间质干细胞有促进作用.

关键词: 5-[2-(8-羟基喹啉-2-基)乙烯基]-2-甲基-8-羟基喹啉, 抗氧化活性, 骨髓间质干细胞

5-[2-(8-Hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol (5) was synthesized and character-ized by IR, UV, 1H NMR, MS spectra and elemental analysis. Meanwhile, the stem cell activity and antioxidation activity of the title compound were investigated by the MTT and DPPH• methods. From the result it can be seen that the title compound has strong antioxidation activity and can induce the proliferation of mesenchymal stem cell under a low concentration condition.

Key words: antioxidation activity, proliferation of mes-enchymal stem cell, 5-[2-(8-hydroxy-quinolin-2-yl)-vinyl]-2-methyl-quinolin-8-ol