SIOC English
有机化学
高级检索

有机化学 ›› 2008, Vol. 28 ›› Issue (08): 1479-1482. 上一篇    下一篇

研究简报

固体酸Amberlyst 15催化合成3-吲哚取代的苯酞类化合物

林 华a ; 韩京成a ; 孙兴文*,a; 林国强*,a,b   

  1. (a复旦大学化学系 上海 200433)
    (b中国科学院上海有机化学研究所 上海 200032)
  • 收稿日期:2008-06-02 修回日期:2008-06-06 发布日期:2008-08-18
  • 通讯作者: 孙兴文*,a; 林国强*,a,b

Synthesis of 3-Indolyl-substituted Phthalides Catalyzed by Acidic Cation Exchange Resin Amberlyst 15

LIN, Huaa ; HAN, Kyong-Sunga ; SUN, Xing-Wen*,a ; LIN, Guo-Qiang*,a,b   

  1. (a Department of Chemistry, Fudan University, Shanghai 200433)
    (b Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032)
  • Received:2008-06-02 Revised:2008-06-06 Published:2008-08-18
  • Contact: SUN, Xing-Wen*,a;LIN, Guo-Qiang*,a,b

PDF

813

被引次数

13 | 2

室温下, 以吲哚和邻甲酰苯甲酸为原料, 通过Amberlyst 15 (15 wt%)催化的傅-克反应, 高产率合成得到一系列3-吲哚取代的苯酞类化合物. 并通过1H NMR, 13C NMR, 红外光谱, 高分辨质谱确证了产物的结构.

关键词: 合成, Amberlyst 15, 3-吲哚取代的苯酞, 吲哚, 傅-克反应, 苯酞

A mild and simple method for the synthesis of 3-indolyl-substituted phthalides via Friedel-Crafts reaction of indoles with 2-formylbenzoic acids catalyzed by an acidic cation exchange resin Amberlyst 15 has been developed. The reaction affords a wide range of 3-indolyl-substituted phthalides in high yield. The structures of the corresponding products were confirmed on the basis of 1H NMR, 13C NMR, IR and HRMS spectra.

Key words: Amberlyst 15, phthalide, synthesis, Friedel-Crafts reaction, 3-indolyl-subtituted phthalide, indole