有机化学 ›› 2008, Vol. 28 ›› Issue (10): 1697-1706. 上一篇    下一篇

综述与进展

植物内生真菌抗肿瘤活性成分研究进展

马养民* ; 冯成亮   

  1. (陕西科技大学化学与化工学院 西安 710021)
  • 收稿日期:2007-11-17 修回日期:2008-01-12 发布日期:2008-10-20
  • 通讯作者: 马养民

Progress in the Studies on Antitumoral Natural Products from Endophytic Fungi

MA, Yang-Min* ; FENG, Cheng-Liang   

  1. (College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021)
  • Received:2007-11-17 Revised:2008-01-12 Published:2008-10-20
  • Contact: MA, Yang-Min

从植物内生真菌中获得了一系列具有多样性结构的抗肿瘤活性化合物. 对植物内生真菌所产生的萜类、生物碱、黄酮、甾体、酯类化合物的结构和对肿瘤细胞的抑制作用、抑制效果, 以及这些内生真菌的寄主植物等几方面进行了综述, 并且简要讨论了这些内生真菌与其寄主植物之间的化学生态学关系.

关键词: 植物内生真菌, 代谢产物, 抗肿瘤活性

A number of antitumoral natural products have been isolated from endophytic fungi with diverse structures. Progress in various studies on antitumoral components is summarized, including the host plants of these endophytic fungi, the isolation and characterization of terpenoids, alkaloids, flavonoids, esters and steroids, and their inhibitory effects against tumor cells. In addition, the chemical ecology relationships between the endophytic fungi and their host plants are also briefly discussed.

Key words: metabolite, endophytic fungus, antitumor