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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (04): 569-574. 上一篇    下一篇

研究论文

双功能有机小分子模拟酯酶研究

杨锦耀; 李雪明 ; 董立亭 ; 宣宜宁 ; 鄢 明*; 姚英明   

  1. (a苏州大学化学化工学院 苏州 215123)
    (b中山大学药学院 精细化工与合成药物工业研究院 广州 510006)
  • 收稿日期:2008-04-30 修回日期:2008-09-11 发布日期:2009-04-20
  • 通讯作者: 鄢 明

Simulation of Esterase with Bifunctional Organic Molecules

Yang, Jingyao ; Li, Xueming; Dong, Liting; Xuan, Yining;
Yan, Ming*; Yao, Yingming
  

  1. (a Department of Chemistry and Chemical Engineering, Suzhou University, Suzhou 215123)
    (b School of Pharmaceutical Sciences, Industrial Institute of Fine Chemicals and Synthetic Drugs,
    Sun Yat-sen University, Guangzhou 510006)
  • Received:2008-04-30 Revised:2008-09-11 Published:2009-04-20
  • Contact: Yan, Ming

PDF

1656

被引次数

7

设计并合成了3个含有硫脲和咪唑基团的双功能有机小分子催化剂, 运用紫外光谱研究了它们对乙酸对硝基苯酯(PNPA)水解的催化活性. 考察了不同的pH条件下, 催化速率常数的变化情况. 发现与硫脲单功能催化剂相比, 双功能有机小分子催化剂具有更高的催化活性.

关键词: 咪唑, 模拟酶, 硫脲, 双功能有机分子, 乙酸对硝基苯酯, 水解反应

Three bifunctional organic catalysts with thiourea (or urea) and imidazole groups were designed and synthesized. Their catalytic activities for hydrolysis of p-nitrophenyl acetate (PNPA) were studied by UV spectrum. The dependence of rate constants on pH was also examined. The bifunctional organic catalysts showed higher catalytic activities than the monofunctional catalyst only with thiourea group.

Key words: enzyme mimic, bifunctional organic molecule, imidazole, hydrolysis, thiourea, nitrophenyl acetate