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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (04): 634-637. 上一篇    下一篇

研究简报

2-芳基-5-(6-哒嗪酮-3-基)-1,3,4-噁二唑的合成

陶 晶* ; 曹玲华   

  1. (a伊犁师范学院生命与资源环境系 奎屯 833200)
    (b新疆大学化学化工学院 乌鲁木齐 830046)
  • 收稿日期:1900-01-01 修回日期:1900-01-01 发布日期:2009-04-20
  • 通讯作者: 陶 晶

Synthesis of 2-Aryl-5-(6-pyridazinon-3-yl)-1,3,4-oxadiazoles

Tao, Jing*; Cao, Linghua   

  1. (a Department of Biology and Resource Environment, Yili Normal College, Kuitun 833200)
    (b College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046)
  • Received:1900-01-01 Revised:1900-01-01 Published:2009-04-20
  • Contact: Tao, Jing

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被引次数

2 | 2

1,4,5,6-四氢-6-哒嗪酮-3-甲酰肼(1)和1,6-二氢-6-哒嗪酮-3-甲酰肼(2)与芳香醛反应得到相应的芳香醛腙3a～3g和5a～5g, 再将3a～3g, 5a～5g在溴的作用下, 合环得到一系列1,3,4-噁二唑的衍生物4a～4g和6a～6g. 化合物的结构经1H NMR, IR, MS和元素分析得以证实.

关键词: 哒嗪酮, 芳香醛腙, 噁二唑

The reaction of 1,4,5,6-tetrahydro-6-pyridazinone-3-carboxylic acid hydrazide (1) and 1,6-dihydro-6-pyridazinone-3-carboxylic acid hydrazide (2) with aromatic aldehydes afforded aromatic al-dehyde hydrazones 3a～3g and 5a～5g. A series of 1,3,4-oxadiazole derivatives 4a～4g and 6a～6g were obtained from 3a～3g and 5a～5g by the cyclization with bromine. Their structures were established by 1H NMR, IR, MS techniques and elemental analysis.

Key words: aromatic aldehyde hydrazone, pyridazinone, oxadiazole