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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (9): 1371-1375. 上一篇    下一篇

研究论文

见血封喉根中类黄酮的结构鉴定

阙东枚 梅文莉 吴 娇 韩 壮 戴好富*   

  1. (中国热带农业科学院热带生物技术研究所 农业部热带作物生物技术重点开放实验室 海口 571101)
  • 收稿日期:2008-12-24 修回日期:2009-02-20 发布日期:2009-12-30
  • 通讯作者: 戴好富

Structure Elucidation of Flavonoids from Antiaris toxicaria Roots

Que, Dongmei Mei, Wenli Wu, Jiao Han, Zhuang Dai, Haofu*   

  1. (Key Laboratory of Tropical Crop Biotechnology, Ministry of Agriculture, Institute of Tropical Bioscience and Biotechnology, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101)
  • Received:2008-12-24 Revised:2009-02-20 Published:2009-12-30
  • Contact: Dai, Haofu

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从海南产见血封喉[Antiaris toxicaria (Pers.) Lesch.]根的乙醇提取物中分离得到8个黄酮类化合物, 分别鉴定为antiarones K, B, F～I (1～6), (±)-sigmoidin A (7)和2-[2,3-二氢-4-羟基-2-(2-羟基-2-丙基)-5-甲氧基-1H-茚基]-1-(2,4,6-三羟基苯基)乙酮(8). 其中antiarone K (1)为新的异戊烯基二氢黄酮. 运用现代波谱技术, 包括二维核磁共振谱和高分辨质谱, 对上述化合物的结构进行了确证. 以上化合物经滤纸片法进行抗菌活性测试, 结果表明化合物1和3均具有抗金黄色葡萄球菌活性, 化合物3还具有抗耐甲氧西林金黄色葡萄球菌(MRSA)活性; 经MTT法进行细胞毒活性测试, 结果表明化合物1和6～8对慢性髓原白血病细胞(K562)、人胃癌细胞(SGC-7901)和人肝癌细胞(SMMC-7721)的增殖显示了生长抑制活性.

关键词: 见血封喉, 异戊烯基二氢黄酮, Antiarone K, 细胞毒活性, 抗菌活性

A new prenylflavanone, antiarone K (1), together with seven known flavonoids, antiarones B, F～I (2～6), (±)-sigmoidin A (7), and 2-[2,3-dihydro-4-hydroxy-2-(2-hydroxy-2-propyl)-5-methoxy-1H- inden-1-yl]-1-(2,4,6-trihydroxyphenyl)ethanone (8), was isolated from the ethanolic extract of the roots of Antiaris toxicaria (Pers.) Lesch collected from Hainan. The structures were established by spectroscopic methods (IR, 1D-, 2D-NMR, and HR-ESIMS). Compounds 1 and 3 possessed inhibitory effects on Staphy-lococcus aureus, and compound 3 possessed inhibitory effects on methicillin-resistant Staphylococcus aureus (MRSA) as shown by the filter paper disc diffusion method. Compounds 1, 6～8 showed inhibitory activity towards chronic myelogenous leukemia (K562), human gastric carcinoma (SGC-7901), and human hepatoma (SMMC-7721) cell lines by MTT assay.

Key words: prenylflavanone, antiarone K, cytotoxicity, antibacterial activity, Antiaris toxicaria