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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (10): 1421-1430.    下一篇

综述与进展

无溶剂反应在杂环合成中的应用进展

余富朝，严胜骄，林军   

  1. (云南大学化学科学与工程学院 教育部自然资源药物化学重点实验室 昆明 650091)
  • 收稿日期:2009-11-12 修回日期:2010-03-08 发布日期:2010-04-02
  • 通讯作者: 林军 E-mail:linjun@ynu.edu.cn;linjunyn@yahoo.com.cn
  • 基金资助:

    国家级.国家自然科学基金

Application of Solvent-Free Reaction in Synthesis of Heterocyclic Compounds

YU Fu-Chao, YAN Sheng-Jiao, LIN Jun   

  1. (Key Laboratory of Medicinal Chemistry for Natural Resource, Ministry of Education, School of Chemical Science and Technology, Yunnan University, Kunming 650091)
  • Received:2009-11-12 Revised:2010-03-08 Published:2010-04-02

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2125

被引次数

64 | 11

杂环化合物在药物和农药领域具有多种优良的生物活性, 其合成方法是目前药物和农药研究的热点领域之一. 以绿色合成为主题, 介绍了无溶剂杂环有机合成在产率高、选择性好、操作简便、成本低及环境友好等绿色化学方面的优点, 综述了近四年无溶剂反应在杂环合成方面研究的最新进展.

关键词: 无溶剂反应, 杂环合成, 杂环化合物, 微波辅助合成

Heterocyclic compounds have shown many excellent biological activities in both area of medicine and pesticide. The synthetic method is one of the focused fields concerning pharmaceutical and pesticidal researches at present. With the theme of green synthesis, some advantadges of organic solvent-free heterocyclic synthesis in high yield, good selectivity, easy operation, low cost and environmental friendship were introduced. And the developments in the recent four years of solvent-free reaction in heterocyclic syn-thesis study have been reviewed.

Key words: solvent-free reaction, heterocyclic synthesis, heterocycle, microwave-synthesis