有机化学 ›› 2010, Vol. 30 ›› Issue (11): 1640-1651. 上一篇    下一篇

综述与进展

卟啉衍生物作为G-四链体DNA结合剂的研究进展

周亭,龙玉华*,杨定乔,刘真权   

  1. (华南师范大学化学与环境学院 广州 510006)
  • 收稿日期:2009-10-27 修回日期:2010-04-13 发布日期:2010-05-18
  • 通讯作者: 龙玉华 E-mail:yuhualong68@hotmail.com
  • 基金资助:

    国家级.国家自然科学基金

Progress in Studies of Porphyrin Derivatives as G-Quadruplex DNA Binders

ZHOU Ting, LONG Yu-Hua, YANG Ding-Qiao, LIU Zhen-Quan   

  1. (School of Chemistry and Environment, South China Normal University, Guangzhou 510006)
  • Received:2009-10-27 Revised:2010-04-13 Published:2010-05-18
  • Contact: Yuhua LONG E-mail:yuhualong68@hotmail.com

综述了卟啉衍生物作为G-四链体DNA结合剂的研究进展, 其中涉及该类化合物作为G-四链体DNA结合剂的设计合成、亲和能力以及端粒酶抑制活性.

关键词: 卟啉, G-四链体DNA结合剂, 端粒酶抑制剂

The research progress in studies of porphyrin derivatives as G-quadruplex binders including their synthetic design, binding affinities and telomerase inhibitory activity is reviewed.

Key words: porphyrin, G-quadruplex DNA binders, telomerase inhibitor