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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (01): 63-67. 上一篇    下一篇

研究论文

新型含吡唑基的α-氨基膦酸酯类衍生物的合成及生物活性

仇记宽1，刘国生2，李建平*,1，赵玉灵1，李会娟1，张贵生1   

  1. (1河南师范大学化学与环境科学学院 黄淮水环境与污染防治省部共建教育部重点实验室 新乡 453007)
    (2河南师范大学生命科学学院 新乡 453007)
  • 收稿日期:2010-03-30 修回日期:2010-06-23 发布日期:2010-08-09
  • 通讯作者: 李建平 E-mail:jplig@163.com
  • 基金资助:

    国家自然科学基金;河南省高校科技创新团队支持计划

Synthesis and Biological Activity of α-Aminophosphonate Derivatives Containing Novel Substituted Pyrazole

Qiu Jikuan1 Liu Guosheng2 Li Jian-ping*,1 Zhao Yuling1 Li Huijuan1 Zhang Guisheng1   

  1. (1 Key Labaratory for Yellow River and Huaihe River Water Environment and Pollution Control, Ministry of Education, College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007)
    (2 College of Life Science, Henan Normal University, Xinxiang 453007)
  • Received:2010-03-30 Revised:2010-06-23 Published:2010-08-09

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在微波无溶剂无催化条件下, 以取代吡唑甲醛、芳胺和亚磷酸二乙酯为原料合成了一系列新型含吡唑基的α-氨基膦酸酯类衍生物, 其结构经1H NMR, 13C NMR, MS和31P NMR测试技术进行了表征. 初步生测结果表明, 部分化合物表现出不同程度的抗菌活性.

关键词: 吡唑, 氨基膦酸酯, 微波无溶剂合成, 抗菌活性

A series of novel α-aminophosphonate derivatives containing substituted pyrazole were synthesized with substituted pyrazolyl aldehyde, arylamine and diethylphosphone under microwave-assisted without using any catalysts and solvent. And the structures of the compounds were confirmed by 1H NMR, 13C NMR, 31P NMR and MS techniques. Preliminary bioassay indicated that some of them showed good fungicidal activities.

Key words: pyrazole, aminophosphonate, microwave-assisted solvent-free synthesis, biological activity