关键词: NH-1,2,3-三唑, 合成, 1,3-偶极环加成, 药物中间体

NH-1,2,3-Triazoles are a kind of N-containing heterocylic compounds with important biological activities, which have found broad use in medicinal intermediates. Besides, NH-1,2,3-triazoles serve as valuable synthetic intermediates for the preparation of 2-substituded-1,2,3-triazoles through N-alkylation reaction. Because of their potent applications in both synthetic organic chemistry and medicinal chemistry, the progess in the synthesis of NH-1,2,3-triazoles, especially those reported in the past decade, is surveyed according to the re-search by our group and other groups. Some classical reaction mechanics are also reviewed in this paper.

Key words: NH-1,2,3-triazole, synthesis, 1,3-dipolar cycloaddition, medicinal intermediate