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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (01): 96-100. 上一篇    下一篇

研究论文

无溶剂条件下离子液体[Hnmp]HSO4催化一锅法合成2 -氨基苯并噻唑-芳甲基-2-萘酚

余意，郭红云*   

  1. (浙江工业大学化学工程与材料学院 杭州 310014)
  • 收稿日期:2010-06-20 修回日期:2010-07-17 发布日期:2010-08-20
  • 通讯作者: 郭红云 E-mail:guohy63@163.com

One-Pot Synthesis of 2 -Aminobenzothiazolo-arylmethyl-2-naphthols in Ionic Liquid of [Hnmp]HSO4 under Solvent-Free Conditions

YU Yi, GUO Hong-Yun   

  1. (College of Chemical Engineering and Material Science, Zhejiang University of Technology, Hangzhou 310014)
  • Received:2010-06-20 Revised:2010-07-17 Published:2010-08-20

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以离子液体[Hnmp]HSO4为催化剂, 在无溶剂条件下催化芳香醛、2-氨基苯并噻唑和2-萘酚合成一系列的2 -氨基苯并噻唑-芳甲基-2-萘酚. 该方法条件温和, 反应时间短, 产率高和对环境友好. 此外催化剂可以方便地回收, 且循环使用四次其催化活性并没有显著降低. 目标产物经过了1H NMR, IR, MS和元素分析确证.

关键词: 三组分反应, 离子液体, 无溶剂, 2 -氨基苯并噻唑-芳甲基-2-萘酚

A series of 2 -aminobenzothiazolo-arylmethyl-2-naphthols were synthesized via three-component reaction of aromatic aldehyde, 2-aminobenzothiazole and 2-naphthol in ionic liquid of [Hnmp]HSO4 under solvent-free conditions. The method provided several advantages such as milder conditions, shorter reaction time, high yields and environmentally benign procedure. Moreover, the catalyst could be recovered conveniently and reused for at least four times without evident loss of activity. The products were identified by 1H NMR, IR, MS techniques and elemental analysis.

Key words: three-component reaction, ionic liquid, solvent-free, 2 -aminobenzothiazolo-arylmethyl-2- naphthol