失配的Lewis对: 非金属催化氢化的新策略

有机化学 ›› 2011, Vol. 31 ›› Issue (9): 1369-1376. 上一篇下一篇

综述与进展

失配的Lewis对: 非金属催化氢化的新策略

王平安*，孙晓莉，高鹏

(第四军医大学药学系化学教研室西安 710032)

收稿日期:2010-12-13 修回日期:2011-01-21 发布日期:2011-02-18
通讯作者: 王平安 E-mail:ping_an1718@yahoo.com.cn

Frustrated Lewis Pairs: A New Strategy for Metal-Free Catalytic Hy-drogenation

WANG Ping-An, SUN Xiao-Li, GAO Peng

(Department of Chemistry, School of Pharmacy, Fourth Military Medical University, Xian 710032)

Received:2010-12-13 Revised:2011-01-21 Published:2011-02-18

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摘要/Abstract

“失配的Lewis对”(Frustrated Lewis Pairs, FLPs)作为有机化学领域的新概念, 在非金属活化H₂, CO₂和NH₃等小分子方面的研究和应用格外引人注目. 以“失配的Lewis对”为催化剂, 直接以氢气作为氢源, 非金属催化氢化还原醛、烯胺、亚胺、腈和二氧化碳等获得了很好的结果. 手性“失配的Lewis对”(Chiral Frustrated Lewis Pairs, Chiral FLPs)在不对称催化氢化还原亚胺的反应中也呈现出较高的光学选择性, 产物胺的对映体过量最高达83% ee. 综述了近几年“失配的Lewis对”在非金属催化氢化研究领域的进展情况.

关键词: 失配的Lewis对, 活化氢分子, 非金属催化氢化

“Frustrated Lewis Pairs” (FLPs) as a new concept in organic chemistry was used in metal-free activation of some small molecules such as H₂, CO₂ and NH₃, and its researches and applications are very attractive to chemists. The good to excellent results were obtained in catalytic hydrogenation of aldehydes, enamines, imines, nitriles and CO₂ by using various FLPs as catalysts and H₂ as hydrogen source. The chiral FLPs also demonstrate good enantioselectivities in metal-free catalytic hydrogenation of imines, and the enantiomeric excess of the corresponding amines is up to 83%. This review describes the development of FLPs for metal-free catalytic hydrogenation in recent years.

Key words: frustrated Lewis pairs, activation of molecular hydrogen, metal-free catalytic hydrogenation

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王平安, 孙晓莉, 高鹏. 失配的Lewis对: 非金属催化氢化的新策略[J]. 有机化学, 2011, 31(9): 1369-1376.

WANG Ping-An, SUN Xiao-Li, GAO Peng. Frustrated Lewis Pairs: A New Strategy for Metal-Free Catalytic Hy-drogenation[J]. Chin. J. Org. Chem., 2011, 31(9): 1369-1376.

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失配的Lewis对: 非金属催化氢化的新策略

Frustrated Lewis Pairs: A New Strategy for Metal-Free Catalytic Hy-drogenation

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