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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (02): 279-282. 上一篇    下一篇

研究简报

新型大环席夫碱化合物的合成及其抗菌活性研究

袁泽利; 胡庆红; 吴 庆; 张铭钦; 朱必学*   

  1. (a遵义医学院药学系 遵义 563003)
    (b贵州大学化学系 贵阳 550025)
  • 收稿日期:2008-04-13 修回日期:2008-08-15 发布日期:2009-02-20
  • 通讯作者: 朱必学

Synthesis and Antibacterial Activity of Novel Schiff Base Macrocyclic Compounds

Yuan, Zeli ; Hu, Qinghong; Wu, Qing ; Zhang, Mingqin ; Zhu, Bixue*   

  1. (a Department of Pharmacy, Zhunyi Medical College, Zhunyi 563003)
    (b Deparment of Chemistry, Guizhou University, Guiyang 550025)
  • Received:2008-04-13 Revised:2008-08-15 Published:2009-02-20
  • Contact: Zhu, Bixue

PDF

1658

被引次数

83 | 20

利用Ca2＋, Ba2＋离子作为模板离子, 由2,4-二羟基-5-乙酰苯乙酮与烷基二胺[即1,3-丙二胺, 1,4-丁二胺, 1,6-己二胺]反应, 分别合成了系列新型席夫碱大环化合物Ln (n＝3, 4, 6). 对合成得到的新型大环席夫碱化合物采用元素分析, 1H NMR, IR, 紫外-可见光谱和MS等进行组成和结构表征, 体外抗菌活性也被试验.

关键词: 抗菌活性
, 烷基二胺, 模板合成法, 席夫碱

Using Ca2＋ or Ba2＋ as the template 2,4-dihydroxy-5-acetylacetophenone was reacted with a series of diamine to yield novel macrocyclic Schiff base compounds (Ln). Their structures were characterized by elemental analysis, 1H NMR, IR, UV-vis and MS techniques, and the in vitro antimicrobial activities were also tested.

Key words: template synthesis, Schiff base, antibacterial activity, diamine