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有机化学
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有机化学 ›› 2003, Vol. 23 ›› Issue (4): 372-374. 上一篇    下一篇

研究论文

(Z)-1-[2-(三苄基锡基)乙烯基]环庚醇及其衍生物的合成和性质

任玉杰;贾翠英;赵玉梅;李平;李华;陈惠麟   

  1. 大连理工大学化学系;中国科学院大连化不物理研究所
  • 发布日期:2003-04-25

Synthesis and Properties of (Z)-1-[2-(Tribenzyistannyl) vinyl]-l- cycioheptanol and Its Benzylhalostannyl Derivatives

Ren YuJie;Jia CuiYing;Zhao YuMei;Li Ping;Li Hua;Chen HuiLin   

  1. Chemistry Department, Dcdian University of Technology;Dalian Institute of Chemical Physics, Chinese Academy of,Sciences
  • Published:2003-04-25

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通过三苄基氢化锡与1-乙快基环庚醇发生加成反应，得到了一种有机锡化合物 ：(Z)-1-[2-(三苄基锡基)乙烯基]环庚醇(1)．化合物1与I2，Br2和IC1按1：1和1 ：2摩尔比投料进行卤化反应，得到6种构型保持的有机锡一卤化物2-4及二卤化物 5-7．有机锡一卤化物3与KOH乙醇溶液反应，得到了相应的有机锡氢氧化物8．以上 8种新化合物均通过熔点测定、元素分析、锡含量测定、红外光谱、核磁共振氢谱 对其结构进行了表征．并对其中的有机锡化合物1，3，4，6，7进行了体外抗P388 血癌活性测定，其中有机锡化合物4，6，7表现出强效．

关键词: 有机锡化合物;庚醇 P;抗癌药;加成反应;元素分析;红外分光光度法, 质子磁共振谱法;结构表征

1-Ethynyl-l-cyeloheptanol reacted with tribenzylstannyl hydride ( C- 6H-5CH-2 )sSnH generating the corresponding (Z)-l-[2-(tribenzylstannyl) vinyl]-1-cycloheptanol (1) . The compound 1 obtained reacted with one or two equivalents of halogen (I-2, Br-2 or IC1) to form the associated ( Z)-l-[2-( dibenzylhalostannyl) vinyl ]-l-cycloheptanol or ( Z)-l-[2 ( benzyldihalostannyl) vinyl]-1-cycloheptanol (2-7), respectively. The organotin hydroxide 8 was prepared by the reaction of 3 with KOH. All compounds were characterized by elemental analysis, IR and H NMR spectra, and the antitumor activity of compounds 1, 3, 4, 6 and 7 was determined. And it was found that they were potent antitumor agents, being effective against P388 cells in mice.

Key words: ORGANO TIN COMPOUNDS;HEPTANOL P;ANTICARCINOGEN;ADDITION REACTION, ELEMENTAL ANALYSIS;IR;1HNMR;STRUCTURE CHARACTERISTICS

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