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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (05): 730-735. 上一篇    下一篇

研究论文

3-芳亚甲基联氨羰基-5-(对位取代苯基)-吡唑衍生物的 合成、结构和生物活性

安 悦*,a ; 牟萍萍a ; 郭志萍a ; 邢永恒a ; 周光华a ; 宁 俊b ;
吕建州b ; 胡皆汉c
  

  1. (a辽宁师范大学化学化工学院 大连 116029)
    (b辽宁师范大学生命科学学院 大连 116029)
    (c中国科学院大连化学物理研究所 大连 116024)
  • 收稿日期:2008-07-04 修回日期:2008-10-24 发布日期:2009-05-20
  • 通讯作者: 安 悦

Synthesis, Structure and Their Biological Activities of 3-Arylmethylide- nehydrazinocarbonyl-5-(p-substituted phenyl)-pyrazole Derivatives

An, Yue*,a ; Mu, Pingpinga; Guo, Zhipinga ; Xing, Yonghenga ; Zhou, Guanghuaa;
Ning, Jun b; Lü, Jianzhou b ; Hu, Jiehanc
  

  1. (a College of Chemistry and Chemical Engineering, Liaoning Normal University, Dalian 116029)
    (b College of Life Sciences, Liaoning Normal University, Dalian 116029)
    (c Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116024)
  • Received:2008-07-04 Revised:2008-10-24 Published:2009-05-20
  • Contact: An, Yue

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1491

被引次数

24

以4-取代苯乙酮及草酸二乙酯为起始原料, 设计合成了20个新的3-芳亚甲基联氨羰基-5-(对位取代苯基)-吡唑衍生物, 产率较高. 所合成的化合物经元素分析, IR, 1H NMR对其结构进行了表征, 化合物4b, 4h还通过X-ray单晶衍射进一步确证了其结构. 初步生物活性实验结果表明, 所合成的化合物对绿豆发芽过程有着较好的生长调节作用.

关键词: 合成, 结构, 生物活性, 吡唑衍生物

Twenty new 3-arylmethylidenehydrazinocarbonyl-5-(p-substituted phenyl)-pyrazole derivatives were designed and synthesized in good to excellent yields using 4-substituted acetophenone and diethyl oxalate as the starting materials. All the new compounds were characterized by elemental analysis, IR and 1H NMR spectra, while compounds 4b and 4h were further characterized by single crystal X-ray diffraction analysis. Besides, the results of primary biological activity experiments on the germination process of mung bean showed that these newly synthesized compounds had good activity.

Key words: synthesis, structure, biological activity, pyrazole derivative