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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (05): 593-596. 上一篇    下一篇

研究论文

3-取代苯氧甲基-6-氯哒嗪的合成及其除草活性

胡方中，常永强，朱有全，刘斌，邹小毛*，杨华铮*   

  1. (南开大学元素有机化学研究所 元素有机化学国家重点实验室 天津 300071)
  • 收稿日期:2006-06-06 修回日期:1900-01-01 发布日期:2007-05-10
  • 通讯作者: 邹小毛*，杨华铮*

Synthesis and Herbicidal Activity of 3-(Substitutedphenoxy-methyl)-6-chloropyridazines

HU Fang-Zhong, CHANG Yong-Qiang, ZHU You-Quan
LIU Bin, ZOU Xiao-Mao*, YANG Hua-Zheng*   

  1. (State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry,
    Nankai University, Tianjin 300071)
  • Received:2006-06-06 Revised:1900-01-01 Published:2007-05-10
  • Contact: ZOU Xiao-Mao*, YANG Hua-Zheng*

PDF

969

被引次数

20 | 1

通过3-氯-6-溴甲基哒嗪与各种取代的苯酚在K2CO3/DMF体系中反应, 合成了一系列3-取代苯氧甲基-6-氯哒嗪化合物. 它们的结构均经1H NMR, IR和元素分析确证. 在浓度为100 μg•mL－1时, 初步的生物活性测试结果表明, 所合成的化合物对油菜和稗草均有一定的抑制作用. 并讨论了其结构与除草活性的关系.

关键词: 合成, 除草活性, 构效关系, 3-取代苯氧甲基-6-氯哒嗪

A series of 3-(substituted phenoxymethyl)-6-chloropyridazine derivatives were synthesized as herbicide candidates by the treatment of different phenols with 3-chloro-6-methylpyridazine in DMF cata-lyzed by K2CO3. The new compounds were identified by 1H NMR, IR spectra and elemental analyses. Preliminary bioassay showed that all of them had herbicidal activity against Brassica napus and Echinochloa crusgalli at 100 mg•mL－1. The structure-activity relationship was discussed.

Key words: synthesis, herbicidal activity, structure-activity relationship, 3-(substituted phenoxymethyl)-6-chloropyridazine