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有机化学
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有机化学 ›› 2007, Vol. 27 ›› Issue (10): 1244-1249. 上一篇    下一篇

研究论文

1-芳基-2-丙酮的合成研究

李丽*,a，刘展鹏b，林原斌b   

  1. (a湖南科技大学化学化工学院 湘潭 411201)
    (b湘潭大学化学学院 湘潭 411105)
  • 收稿日期:2006-11-01 修回日期:2007-02-16 发布日期:2007-09-28
  • 通讯作者: 李丽

Study on Synthesis of 1-Aryl-2-propanones

LI Li*,a,LIU Zhan-Pengb,LIN Yuan-Binb   

  1. (a School of Chemistry and Chemical Engineering, Hunan University of Science and Technol-ogy, Xiangtan 411201)
    (b College of Chemistry, Xiangtan University, Xiang-tan 411105)
  • Received:2006-11-01 Revised:2007-02-16 Published:2007-09-28
  • Contact: LI Li

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以芳香胺为原料, 经重氮化和改进的Meerwein芳基取代反应, 合成了一系列的1-芳基-2-丙酮, 其中1-(3,5-二三氟甲基苯基)-2-丙酮是一个新化合物. 改进后的方法简化了合成步骤, 提高了收率, 可方便地用于在苯环上具有不同取代基的芳基丙酮的合成.

关键词: 1-芳基-2-丙酮, 芳香胺, 氟硼酸重氮盐, 改进的Meerwein芳基取代反应

A new convenient synthesis of a series of 1-aryl-2-propanones using aromatic amines as precursors, via diazo reaction and improved Meerwein arylation reaction under mild conditions, was achieved. In addition, 1-[3,5-bis(trifluoromethyl)phenyl]-2-propanone is a new compound among the synthesized compounds. This approach is an efficient synthetic method for the aryl-propanones with the different substituting groups．

Key words: aromatic amine, improved Meerwein arylation reaction, diazonium tetra-fluoroborate, 1-aryl-2-propanone