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有机化学
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有机化学 ›› 1995, Vol. 15 ›› Issue (1): 30-34. 上一篇    下一篇

研究论文

磷酰氨基酸的酯交换反应研究

谭波;赵玉芬   

  1. 清华大学化学系
  • 发布日期:1995-02-25

Ester exchange reaction of phosphoamino acids

TAN BO;ZHAO YUFEN   

  • Published:1995-02-25

被引次数

29

本文利用^3^1P NMR , 对比研究了磷酰化组氨酸与其它磷酰化氨基酸和一级醇的磷上酯交换的反应速度,实验表明磷酰化组氨酸的反应速度最快. 由此提出了以下机理:由于咪唑环的参与,磷可以形成六配位过渡态,从而加快了反应速度.

关键词: 磷酰化合物, 酯交换, 过渡态, 组氨酸, 六配位

In this paper, the relative rate of the ester exchange reaction of the phosphoryl histidine (N-DIPP-His) and other phosphoamino acids with primary alcohols was compared by ^3^!P NMR spectra. It showed that N-DIPP-His was the fastest one. The mechanism was proposed that due to the participation of the imidazole group, the phosphorus could be transformed into a hexa-coordinate transition state which was much favorable for the group exchange reaction.

Key words: TRANSESTERIFICATION, HISTIDINE, PHOSPHORYL COMPOUNDS, TRANSITION STATE, HEXACOORDINATE

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