麝香草的新单萜配糖物的分离与合成

摘要/Abstract

从麝香草(Thymus vulgaris L)的甲醇萃取物中分离出三个单萜配糖物. 用核磁共振光谱确定了它们的结构为对伞花-9-基-β-D-葡糖苷(1), 5-β-D-葡糖苷百里氢醌(2)和2-β-D-葡糖苷百里氢醌(3). 其中1是新化合物, 用以对伞花-9-醇为原料的对映体选择性合成方法确定了化合物1的8位的立体化学为R型.

关键词: (R)-对伞花-9-基-β-D-葡糖苷, 麝香草, 单萜配糖物

Three monoterpene glucosides were isolated from the methanol extract of thyme (Thymus vul-garis L.). They were identified as p-cymen-9-yl-β-D-glucopyranoside (1), 5-β-D-glucopyranosylthymoquinol (2) and 2-β-D-glucopyranosylthymoquinol (3) by spectral evidence. 1 is a new compound, but 2 and 3 are known compounds. The stereochemistry at C-8 of 1 was elucidated to be R-form by enantioselective synthesis from p-cymen-9-ol.

Key words: thyme, monoterpene glucoside, p-cymen-9-yl-β-D-glucopyranoside

引用此文

陆占国,竹内宏之. 麝香草的新单萜配糖物的分离与合成[J]. 有机化学, 2006, 26(01): 51-55.

LU Zhan-Guo*^,1,TAKEUCHI Hiroyuki². Synthesis and Isolation of a New Monoterpene Glucoside from Thyme[J]. Chin. J. Org. Chem., 2006, 26(01): 51-55.

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