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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (10): 1414-1417. 上一篇    下一篇

研究简报

无溶剂条件下合成顺/反3-芳基亚甲基-2,3-二氢-吲哚-2-酮类化合物

徐天图，汪顺义，纪顺俊*   

  1. (苏州大学化学化工学院 江苏省有机合成重点实验室 苏州 215123)
  • 收稿日期:2005-11-16 修回日期:2006-02-20 发布日期:2006-09-19
  • 通讯作者: 纪顺俊

Facile Synthesis of Z/E-3-Arylmethylidene-2,3-dihydroindol-2-one under Solvent-Free Conditions

XU Tian-Tu,WANG Shun-Yi,JI Shun-Jun*   

  1. (Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineer-ing,
    Suzhou University, Suzhou 215123)
  • Received:2005-11-16 Revised:2006-02-20 Published:2006-09-19
  • Contact: JI Shun-Jun

PDF

1043

被引次数

20

无溶剂条件下, 芳香醛与2-吲哚酮在碱性条件下通过研磨, 方便有效地合成了一系列3-芳基亚甲基-2,3-二氢- 吲哚-2-酮类化合物, 该反应条件温和, 时间短, 产率高, 对环境友好. 产物的结构得到1H NMR, IR, HRMS的表征, 其中(Z)-3e和(Z)-3j的结构得到了X单晶衍射的进一步确证.

关键词: 无溶剂, 3-芳基亚甲基-2,3-二氢-吲哚-2-酮类化合物, Knoevenagel缩合, 吲哚酮

A series of 3-arylmethylidene-2,3-dihydroindol-2-one derivatives 3 were conveniently synthesized by the condensation of aromatic aldehydes with 2-dihydroindol-2-one under basic and solvent-free conditions by grinding. All the products were determined by 1H NMR, IR, and HRMS spectra, with the configurations of (Z)-3e and (Z)-3j confirmed by X-ray analysis.

Key words: 3-arylmethylidene-2,3-dihydroindol-2-one, 2-oxoindole, knoevenagel condensation, solvent-free