有机化学 ›› 2005, Vol. 25 ›› Issue (08): 930-933. 上一篇    下一篇

研究论文

无溶剂一锅法合成1,4-二氢吡啶

蔡小华,张国林*   

  1. (1中国科学院成都生物研究所 成都 610041)
    (2中国科学院成都有机化学研究所 成都 610041)
  • 收稿日期:2004-09-20 修回日期:2005-02-01 发布日期:2005-07-30
  • 通讯作者: 张国林

One-pot Synthesis of Dihydropyridines under Solvent-free Condition

CAI Xiao-Hua,ZHANG Guo-Lin*   

  1. (1 Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041)
    (2 Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041)
  • Received:2004-09-20 Revised:2005-02-01 Published:2005-07-30
  • Contact: ZHANG Guo-Lin

碳酸氢铵、醛和1, 3-二羰基化合物于70 ℃无溶剂条件下缩合以86~97%的产率得到1, 4-二氢吡啶.

关键词: 1,4-二氢吡啶, 1,3-二羰基化合物, 无溶剂

One-pot condensation of 1,3-dicarbonyl compounds with a range of aldehydes in the presence of ammonium bicarbonate was carried out under solvent-free condition at 70 ℃ to afford 1,4-dihydro- pyridines in 86%~97% yields.

Key words: solvent-free, 1,3-dicarbonyl compound, 1,4-dihydropyridine