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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (9): 1291-1294. 上一篇    下一篇

研究简报

α-酮酯和α-酮酰胺的Henry反应

王亚军，沈宗旋，张雅文*   

  1. (苏州大学化学化工学院 江苏省有机合成重点实验室 苏州 215006)
  • 收稿日期:2005-10-17 修回日期:2006-01-11 发布日期:2006-09-11
  • 通讯作者: 张雅文

Henry Reaction of α-Ketoesters and α-Ketoamides

WANG Ya-Jun,SHEN Zong-Xuan,ZHANG Ya-Wen*   

  1. (Key Laboratory of Organic Synthesis of Jiangsu Province, College of Chemistry and Chemical Engineering,
    Suzhou University, Suzhou 215006)
  • Received:2005-10-17 Revised:2006-01-11 Published:2006-09-11
  • Contact: ZHANG Ya-Wen

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用三乙胺催化环状α-酮酯和α-酮酰胺同硝基甲烷的Henry反应, 首次合成了12个多官能团的β-硝基醇, 它们的结构用元素分析、红外光谱和核磁共振进行了表征. 这一反应速度较快, 室温下进行, 条件温和, 产率较好, 是合成多官能团硝基醇的有效方法.

关键词: Henry反应, β-硝基醇, 三乙胺, α-酮酰胺, α-酮酯

The Henry reaction of cyclic α-ketoesters and α-ketoamides was achieved using triethylamine as a promoter. Twelve new multi-functional β-nitroalcohols were synthesized. Their structures were confirmed by elemental analyses, IR, 1H NMR or 13C NMR spectroscopy. β-Nitroalcohols were produced in high yields under mild reaction conditions.

Key words: triethylamine, β-nitroalcohol, α-ketoester, α-ketoamide, Henry reaction