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有机化学
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有机化学 ›› 2008, Vol. 28 ›› Issue (06): 1115-1118. 上一篇    下一篇

研究简报

氧官能化的膦配体在钯催化的Suzuki-Miyaura反应中的应用

贾莉a，于宏伟b,c，童庆松a，施继成*<sup>,<i>a</i>,<i>c</sup></i>，金子林<i><sup>b</i>   

  1. (<i><sup>a</sup></i>福建师范大学化学与材料学院 福建省高分子材料重点实验室 福州 350007)<br>(<i><sup>b</sup></i>大连理工大学精细化学国家重点实验室 大连 116012)<br>(<i><sup>c</sup></i>中国科学院大连化学物理研究所 大连 116023)
  • 收稿日期:2007-08-21 修回日期:2007-12-20 发布日期:2008-06-26
  • 通讯作者: 施继成

Application of Oxygen-Functionalized Phosphines as Supporting Ligands in the Palladium-Catalyzed Suzuki-Miyaura Reaction

JIA, Lia, YU, Hong-Weib, TONG, Qing-Songa, SHI, Ji-Cheng*,a,c , JIN, Zi-Linb   

  1. (<i><sup>a</sup> Key Laboratory of Polymer Materials of Fujian Province</i>,<i> College of Chemistry and Materials Sci-ence</i>,<i> </i><br><I>Fujian Normal University</i>,<i> Fuzhou 350007</i>)<br>(<i><sup>b</sup> State Key Labora-tory of Fine Chemicals</i>,<i> Dalian University of Technology</i>,<i> Dalian 116012</i>)<br>(<i><sup>c</sup> Dalian Institute of Chemical Physics</i>,<i> Chinese Academy of Sciences</i>,<i> Dalian 116023</i>)<i>
  • Received:2007-08-21 Revised:2007-12-20 Published:2008-06-26
  • Contact: SHI, Ji-Cheng

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被引次数

18 | 4

合成了带甲氧基和羟基官能团的二茂铁膦配体, 评价了它们在钯催化的Suzuki-Miyaura偶联反应中的性能, 发现带甲氧基的膦配体对钯催化的Suzuki-Miyaura偶联反应有更好的性能, 可催化富电子溴代芳烃和缺电子氯代芳烃与苯硼酸反应高产率地生成相应的联芳烃产物.

关键词: 膦配体, 联芳烃, 氧官能化, C—C键形成反应, Pd催化剂

Ferrocenyl phosphines with methoxy and hydroxy groups have been synthesized and evaluated as supporting ligands in the palladium-catalyzed Suzuki-Miyaura cross-coupling reaction. It was found that the phosphine having methoxy group as supporting lidand afforded better palladium catalyst with Pd(OAc)<sub>2</sub>, which can catalyze electron-rich aryl bromides and electron-deficient aryl chlorides to couple with phenylboronic acid to form the corresponding biaryls in high yields.

Key words: oxygen-functionalizing, biaryl, Pd catalyst, C—C bond-forming reaction, phosphine