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有机化学
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有机化学 ›› 2006, Vol. 26 ›› Issue (02): 256-259. 上一篇    下一篇

研究简报

KF/Al2O3催化下吡啶并[2,3-d]嘧啶衍生物的三组分一步合成

王香善*,1,2,3，曾兆森2，史达清2,3，屠树江2,3
魏贤勇1，宗志敏1   

  1. (1中国矿业大学化学工程学院 徐州 221008)
    (2徐州师范大学化学系 徐州 221116)
    (3江苏省药用植物生物技术重点实验室 徐州 221116)
  • 收稿日期:2005-02-21 修回日期:2005-08-26 发布日期:2006-01-21
  • 通讯作者: 王香善

Three Component One-Pot Synthesis of Pyrido[2,3-d]pyrimidineDerivatives Catalyzed by KF-alumina

WANG Xiang-Shan*,1,2,3,ZENG Zhao-Sen2,SHI Da-Qing2,3,TU Shu-Jiang2,3
WEI Xian-Yong1,ZONG Zhi-Min1   

  1. (1 School of Chemical Engineering, China University of Mining and Technology, Xuzhou 221008)
    (2 Department of Chemistry, Xuzhou Normal University, Xuzhou 221116)
    (3 Key Laboratory of Biotechnology on Medical Plant of Jiangsu Prov-ince, Xuzhou 221116)
  • Received:2005-02-21 Revised:2005-08-26 Published:2006-01-21
  • Contact: WANG Xiang-Shan

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以芳醛、丙二腈和2,6-二羟基-4-氨基嘧啶为原料, 在KF/Al2O3催化下以乙醇为溶剂, 在80 ℃三组分一步合成了一系列吡啶并[2,3-d]嘧啶衍生物, 有趣的是在空气氧化作用下进一步发生了芳构化作用. 和其它合成方法相比, 该方法具有反应条件温和、容易操作和产率较高等优点, 并通过IR, 1H NMR和元素分析确证产物的结构.

关键词: 吡啶并[2, 3-d]嘧啶, 芳构化, 合成, KF/Al2O3

A series of pyrido[2,3-d]pyrimidine derivatives were synthesized by the three component reaction of arylaldehyde, malononitrile and 4-amino-2,6-dihydroxylpyrimidine in ethyl alcohol at 80 ℃ catalyzed by KF-Al2O3. It was interesting that the further aromatization took place by air oxidation. Compared with other synthetic methods, this new method has the advantage of easier work-up, milder reaction conditions and good yields. The structure of the products was characterized by IR, 1H NMR spectra and elemental analysis.

Key words: aromatization, KF-Al2O3, synthesis, pyrido[2,3-d]pyrimidine