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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (11): 1784-1789. 上一篇    下一篇

研究论文

3-(1′-烃氧亚氨基)乙基-4-羟基吡咯啉-2-酮类衍生物的合成与生物活性

朱宪杰a    黄林a    王先锋a,b    朱兆勇a    郑晓倩a       强胜c       杨春龙*,a,b   

  1. (a南京农业大学理学院化学系 南京 210095) (b南京农业大学农业部病虫监测与防控重点开放实验室 南京 210095) (c南京农业大学生命科学学院 南京 210095)
  • 收稿日期:2009-01-13 修回日期:2009-04-24 发布日期:2009-06-16
  • 通讯作者: 杨春龙 E-mail:chunlongyang@yahoo.com.cn
  • 基金资助:

    国家级.863计划

Synthesis and Biological Activities of 3-(1′-Alkyloxyimino)ethyl-4-hydroxy-pyrroline-2-one Derivatives

Zhu, Xianjiea     Huang, Lina     Wang, Xianfeng a,b    Zhu, Zhaoyonga     Zheng, Xiao-qiana      Qiang, Shengc  Yang, Chunlong*,a,b   

  1. (a Department of Chemistry, College of Science, Nanjing Agricultural University, Nanjing 210095) (b Key Laboratory of Monitoring and Management of Crop Diseases and Pest Insects, Ministry of Agriculture, Nanjing Agricultural University, Nanjing 210095) (c College of Life Science, Nanjing Agricultural University, Nanjing 210095)
  • Received:2009-01-13 Revised:2009-04-24 Published:2009-06-16

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以氨基酸乙酯为原料合成8种3-乙酰基-4-羟基吡咯啉-2-酮的类似物A, A与3种烃氧基胺盐酸盐反应合成了20个肟醚类衍生物3-(1'-烃氧亚氨基)乙基-4-羟基吡咯啉-2-酮(B), 其结构经 1H NMR, MS, IR和元素分析表征. 初步生物活性测定结果表明合成的化合物B具有一定的除草活性和抑制真菌活性.

关键词: 肟醚, 吡咯啉-2-酮, 除草活性, 杀菌活性

3-Acetyl-4-hydroxypyrroline-2-one analogues (A) were synthesized using amino acid ethyl esters as starting material, which were reacted with alkyloxyamine hydrochlorides to give twenty oxime ether derivatives 3-(1'-alkyloxyiminoethyl)-4-hydroxypyrroline-2-ones (B). Structures of all the new compounds were confirmed by 1H NMR, MS, IR data and elemental analysis. The preliminary bioassay results indicated that this kind of compounds exhibited certain herbicidal and antifungal activities.

Key words: oxime ether, pyrroline-2-one, herbicidal activity, antifungal activity