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有机化学
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有机化学 ›› 2009, Vol. 29 ›› Issue (11): 1774-1783. 上一篇    下一篇

研究论文

3a, 4-二氢-苯并吡喃[4,3-c]吡唑-3(2H)-酮类衍生物的合成及其活性

周中振a,b     陈琼*,a       杨光富a   

  1. (a华中师范大学农药与化学生物学教育部重点实验室 武汉 430079) (b南方医科大学药学院 广州 510515)
  • 收稿日期:2008-12-23 修回日期:2009-04-20 发布日期:2009-06-18
  • 通讯作者: 陈琼 E-mail:qchen@mail.ccnu.edu.cn
  • 基金资助:

    国家级.国家自然科学基金

The Synthesis and Activities of 3a, 4-Dihydro chromeno [4, 3-c] pyrazol-3(2 H)-one derivatives

Zhou, Zhongzhen a,b     Chen, Qiong*,a      Yang, Guangfua   

  1. (a Key Laboratory of Pesticide & Chemical Biology of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079) (b School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515)
  • Received:2008-12-23 Revised:2009-04-20 Published:2009-06-18

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设计合成了33种新型的3a, 4-二氢-苯并吡喃[4,3-c]吡唑-3(2H)-酮类化合物，其结构经MS，1H NMR和元素分析的确证。并对化合物7k的单晶进行了结构测定。初步生物活性测试表明标题化合物具有一定的杀虫杀菌活性。

关键词: 苯并吡喃[4,3-c]吡唑, 合成, 杀虫活性, 杀菌活性

We designed and synthesized 33 novel 3a, 4-dihydro-3a-methyl- chromeno [4, 3-c] pyrazol- 3(2 H)-one derivatives. The structures of the target compounds were determined by means of MS, 1H NMR and elemental analysis. The crystal structure of the target compound 7k was determined by X-ray diffraction analysis. At the same time, preliminary bioassay showed that part of them had insecticidal activities and antibacterial activity.

Key words: 2,3a-dihydrochromeno[4,3-c]pyrazol-3-one, synthesis, insecticidal activity, fungicide activity