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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (04): 606-610. 上一篇    下一篇

研究简报

离子液体中酮肟O-烷基化反应的研究

张胜建*，张洪，石园庆，毛红雷   

  1. (浙江大学宁波理工学院 宁波 315100)
  • 收稿日期:2009-07-19 修回日期:2009-09-25 发布日期:2010-04-28
  • 通讯作者: 张胜建 E-mail:zsj@nit.zju.edu.cn

O-Alkylation of Ketone Oxime in Ionic Liquids

Zhang Shengjian* Zhang Hong Shi Yuanqin Mao Honglei   

  1. (Ningbo Institute of Technology, Zhejiang University, Ningbo 315100)
  • Received:2009-07-19 Revised:2009-09-25 Published:2010-04-28
  • Contact: ZHANG Sheng-Jiang E-mail:zsj@nit.zju.edu.cn

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以[Bmim]PF6, [Bmim]BF4, [Bmim]OH为介质, 以NaOH为缚酸剂, 由酮肟与卤烷、硫酸酯等烷基化剂在20～40 ℃反应1～2 h, 以52%～94%的收率制备了酮肟醚衍生物, 产物结构经1H NMR, GC-MS表征. 结果表明, 该方法简便易操作, 所用离子液体对环境友好, 并可循环使用．

关键词: 离子液体, 酮肟, O-烷基化, O-烷基酮肟醚

A series of ketone oxime ethers were synthesized by O-alkylation of ketone oxime with several alkylating agents such as alkyl halides and alkyl sulfates in ionic liquids. The O-alkylation reactions were conducted in 20～40 ℃ for 1～2 h, using ionic liquids [Bmim]PF6, [Bmim]BF4 and [Bmim]OH as medium and NaOH as acid binding agent. The yields of 52%～94% were obtained and the products were identified by 1H NMR and GC-MS techniques. The study shows that the operation conditions are mild, the process is simple and green to environment, and the ionic liquids could be reused while maintaining good performance.

Key words: ionic liquid, ketone oxime, O-alkylation, O-alkyl ketone oxime ether

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