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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (11): 1774-1777. 上一篇    下一篇

研究简报

含有薁类结构的1,4-二氢吡啶衍生物的合成

王道林*，林力男，李少飞，李伟，李元峰   

  1. (渤海大学化学化工学院 辽宁省功能化合物合成与应用重点实验室 锦州 121003)
  • 收稿日期:2010-02-03 修回日期:2010-05-31 发布日期:2010-09-09
  • 通讯作者: 王道林 E-mail:wangdaolin@bhu.edu.cn,wangdaolin@sina.com.cn

Synthesis of 1,4-Dihydropyridines Containing Azulenes Moiety

WANG Dao-Lin, LIN Li-Nan, LI Shao-Fei, LI Wei, LI Yuan-Feng   

  1. (Liaoning Key Laboratory of Synthesis and Application of Functional Compound, College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121003)
  • Received:2010-02-03 Revised:2010-05-31 Published:2010-09-09

PDF

1396

被引次数

13

在对甲基苯磺酸作用下, 以1-甲酰基薁-3-甲酸甲酯、乙酰乙酸酯、醋酸铵或3-氨基巴豆酸酯为原料, 进行三组分一锅法缩合, 以较优的收率制备了含有薁类结构的新的1,4-二氢吡啶类衍生物, 该反应收率良好、操作简单、条件温和. 产物的结构经1H NMR, IR及元素分析等得以证实.

关键词: 薁, 1-甲酰基薁-3-甲酸甲酯, 1,4-二氢吡啶, 合成

New 1,4-dihydridine derivatives containing azulene moiety were synthesized by three component one-pot condensation of methyl 1-formoylazulene-3-carboxylate, acetoacetic esters and ammonium acetate or alkyl 3-amminocrotonate under p-toluenesulfonic acid as a catalyst. This method provides several advantages such as good yield and simple work-up procedure. All the products were fully characterized by 1H NMR, IR spectra and elemental analysis.

Key words: azulene, methyl 1-formoylazulene-3-carboxylate, 1,4-dihydridine, synthesis