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有机化学
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有机化学 ›› 2010, Vol. 30 ›› Issue (11): 1745-1753. 上一篇    下一篇

研究简报

两种新的多羟基甾醇化合物分离与结构鉴定

张福勇，王楠，耿华伟，廖小建，徐石海*   

  1. (暨南大学化学系 广州 510632)
  • 收稿日期:2009-12-22 修回日期:2010-05-11 发布日期:2010-06-17
  • 通讯作者: 徐石海 E-mail:txush@jnu.edu.cn
  • 基金资助:

    珊瑚中抗肿瘤活性化合物的分离与结构鉴定;Ircinia属海绵中抗肿瘤活性化合物的发现与优化

Isolation and Identification of Two New Polyhydroxysteroids

ZHANG Fu-Yong, WANG Nan, GENG Hua-Wei, LIAO Xiao-Jian, XU Shi-Hai   

  1. (Department of Chemistry, Jinan University, Guangzhou 510632)
  • Received:2009-12-22 Revised:2010-05-11 Published:2010-06-17
  • Contact: XU Shi-Hai E-mail:txush@jnu.edu.cn

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被引次数

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采用现代分离手段, 从采自中国南海硇洲岛的软珊瑚Chromonephthea sp. 中分离纯化得到两种甾醇化合物, 经过MS, IR, 1H NMR, 13C NMR (DEPT), HSQC, HMBC和NOE等光谱技术鉴定它们的结构为: 24-甲基胆甾-5-烯- 3β,12β,16β,20-四醇(1)和24-乙基胆甾-5-烯-3β,12β,16β,20-四醇(2), 这两个化合物均为新化合物. 肿瘤活性实验表明两种甾醇化合物显示微弱的细胞毒性.

关键词: 软珊瑚, Chromonephthea sp., 多羟基甾醇, 结构鉴定

Two new polyhydroxysteroids have been isolated from Chromonephthea sp. collected from Naozhou Islands of the South China Sea. Their structures were established as 24-methylcholest-5-en- 3β,12β,16β,20-tetraol (1) and 24-ethylcholest-5-en-3β,12β,16β,20-tetraol (2) by MS, IR, 1H NMR, 13C NMR (DEPT), HSQC, HMBC and NOE techniques. Both of them are previously unknown compounds and showed weak cytotoxicity against the cancer cell lines.

Key words: coral, Chromonephthea sp., polyhydroxysteroid, identification