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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (11): 1905-1908. 上一篇    下一篇

研究简报

三组分一锅法合成3-甲基-1-苯基-4-芳基-4,11-二氢-4H-吡唑并[4,5:3,2]吡啶并[5,6-c]香豆素

林志兰，陈文秀，张雪利，高原*   

  1. (深圳大学化学与化工学院 深圳 518060)
  • 收稿日期:2011-03-30 修回日期:2011-05-11 发布日期:2011-06-10
  • 通讯作者: 高原 E-mail:szgaoy@tom.com

Three-Component One-Pot Synthesis of 4-Aryl-3-methyl-1-phenyl- 4,11-dihydro-4H-pyrazolo[4,5:3,2]pyrido[5,6-c]coumarin

LIN Zhi-Lan, CHEN Wen-Xiu, ZHANG Xue-Li, GAO Yuan   

  1. (College of Chemistry and Chemical Engineering, Shenzhen University, Shenzhen 518060)
  • Received:2011-03-30 Revised:2011-05-11 Published:2011-06-10

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以芳醛、4-羟基香豆素和3-甲基-1-苯基-5-氨基吡唑为原料, 用少量冰醋酸作溶剂, 三组分一锅法合成一系列吡唑并[4,5:3,2]吡啶并[5,6-c]香豆素衍生物, 该反应产率高(79%～94%)、操作简单、后处理方便. 产物的结构经红外光谱、核磁共振氢谱、元素分析及单晶X射线分析证实.

关键词: 香豆素衍生物, 吡唑并吡啶, 三组分一锅反应

A series of pyrazolo[4,5:3,2]pyrido[5,6-c]coumarin derivatives were synthesized by the three component one-pot reaction of 5-amino-3-methyl-1-phenypyrazole with aromatic aldehydes and 4-hydroxy- coumarin in acetic acid. This method has the advantages of excellent yields (79%～94%) and simple workup procedure. The structures of the products were identified by IR, 1H NMR spectra, elemental analysis and X-ray crystallograghic of 4f.

Key words: coumarin derivative, pyrazolopyridine, three component one-pot reaction