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有机化学
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有机化学 ›› 2011, Vol. 31 ›› Issue (11): 1909-1913. 上一篇    下一篇

研究简报

酸性离子液体催化下一锅三组分反应合成N-(2-羟基-1-萘基)(苯基)甲基-吡咯烷-2-酮衍生物

田金金，郭红云*，邵鸿斌   

  1. (浙江工业大学化学工程与材料学院 杭州 310014)
  • 收稿日期:2011-04-08 修回日期:2011-05-17 发布日期:2011-06-17
  • 通讯作者: 郭红云 E-mail:guohy63@163.com

One-Pot Three-Component Synthesis of N-(2-Hydroxynaphthalen- 1-yl)(phenyl)methyl-pyrrolidin-2-ones Catalyzed by Acidic Ionic Liquid [Hnmp]HSO4

TIAN Jin-Jin, GUO Hong-Yun, SHAO Hong-Bin   

  1. (College of Chemical Engineering and Material Science, Zhejiang University of Technology, Hangzhou 310014)
  • Received:2011-04-08 Revised:2011-05-17 Published:2011-06-17

PDF

978

被引次数

1

在无溶剂条件下, 利用廉价无毒的酸性离子液体[Hnmp]HSO4为催化剂, 醛、2-萘酚和吡咯烷酮一锅三组分合成了一系列新颖的N-(2-羟基-1-萘基)(苯基)甲基-吡咯烷-2-酮衍生物. 与现有的方法相比该方法避免使用有机溶剂, 且反应时间短, 产率高, 离子液体廉价易制备, 且可回收重复再利用.

关键词: 酸性离子液体, 2-萘酚, 吡咯烷酮, N-(2-羟基-1-萘基)(苯基)甲基-吡咯烷-2-酮衍生物

A series of novel N-(2-hydroxynaphthalen-1-yl)(phenyl)methyl-pyrrolidin-2-ones were synthesized employing a one-pot three-component condensation reaction of aromatic aldehydes, 2-naphthol and pyr-rolidin-2-one catalyzed by [Hnmp]HSO4 under solvent-free conditions. This method does not involve any hazardous organic solvent and has the advantages of short reaction time, high yields compared with the reported methods. Moreover, the ionic liquid is easy to prepared and could be recycled for subsequent reactions.

Key words: acidic ionic liquid, 2-naphthol, pyrrolidin-2-one, N-(2-hydroxynaphthalen-1-yl)(phenyl)- methyl-pyrrolidin-2-one