有机化学 ›› 2012, Vol. 32 ›› Issue (07): 1186-1194.DOI: 10.6023/cjoc1110191 上一篇    下一篇

综述与进展

离子液体中脂肪酶催化酯类合成的新进展

李晶a, 王俊a, 张磊霞a, 顾双双a, 吴福安a,b, 郭跃伟a,c   

  1. a 江苏科技大学生物与化学工程学院 镇江 202018;
    b 中国农业科学院蚕业研究所 镇江 212018;
    c 中国科学院上海药物研究所新药研究国家重点实验室 上海 201203
  • 收稿日期:2011-10-19 修回日期:2011-12-25 发布日期:2012-02-17
  • 通讯作者: 王俊 E-mail:jimwang_js@hotmail.com
  • 基金资助:
    国家自然科学基金面上(No. 20876076);江苏省高校“青蓝工程”优秀青年骨干教师资助计划(No. 2010);江苏省自然科学基金面上(No. BK2009213);江苏省科技支撑计划(农业)(No. BE2010419);现代农业产业技术体系建设专项(No. CARS-22)及江苏科技大学科研(Nos. 35211002, 33211002)资助项目.

Progress of Lipase-Catalyzed Ester Synthesis in Ionic Liquid

Li Jinga, Wang Juna, Zhang Leixiaa, Gu Shuangshuanga, Wu Fuana,b, Guo Yueweia,c   

  1. a College of Biological and Chemistry, Jiangsu University of Science and Technology, Zhenjiang 212018;
    b The Sericultural Research Institute, Chinese Academy of Agricultural Sciences, Zhenjiang 212018;
    c State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Science, Shanghai 201203
  • Received:2011-10-19 Revised:2011-12-25 Published:2012-02-17
  • Supported by:
    Project supported by the Surface Project of the National Natural Science Foundation of China (No. 20876076), the “Youth Project” Outstanding Young Teachers Aid of Jiangsu Prvince Colleges (No. 2010), the Surface Project of Jiangsu Natural Science Foundation of Jiangsu Province (No. BK2009213), the Scientific Support Plan of Jiangsu Province (Agriculture) (No. BE2010419), the Construction of the Modern Agricultural Industrial Technology System (No. CARS-22) and the Scientific Projects of Jiangsu University of Science and Technology (Nos. 35211002, 33201002).

作为21 世纪最具发展潜力的绿色溶剂, 离子液体用于酶促合成的反应介质具有得天独厚的优势. 与传统的有机溶剂相比, 离子液体能够提高脂肪酶的稳定性和选择性, 减少有机合成中的副反应和有毒气体的产生, 后处理简单, 可重复利用. 参考10 年来的文献, 从脂肪酶催化酯类合成的常用离子液体种类、过程因素及场/反应器强化等方面进行 了综述, 同时展望了离子液体在未来酯类酶促合成领域的发展趋势.

关键词: 离子液体, 脂肪酶, 酯类合成, 过程因素, 场/反应器强化

As one of the most potential green solvents in the 21st century, ionic liquid has been used as reaction media in the enzymatic synthesis with enormous advantages. Compared with conventional organic media, ionic liquid could improve the stability and selectivity of lipase, reduce side reactions, eliminate toxicant organic gas, simplify the post-processing, and be renewable. Combined with the recent decade’s references, this review is focused on summarizing various ionic liquids as the media, process factors, strengthening effect of field and bioreactors in the lipase-catalyzed ester synthesis process. Moreover, some future perspectives on enzymatic synthesis in ionic liquid are discussed.

Key words: ionic liquids, lipase, ester synthesis, process factor, strengthening effect of field and bioreactor