近年来紫杉醇的合成研究进展

doi:10.6023/cjoc201209033

有机化学 ›› 2013, Vol. 33 ›› Issue (03): 458-468.DOI: 10.6023/cjoc201209033 上一篇下一篇

综述与进展

近年来紫杉醇的合成研究进展

唐培^a,b, 王锋鹏^b

a 重庆大学创新药物研究中心生物工程学院重庆 401331;
b 四川大学华西药学院天然药物化学教研室成都 610041

收稿日期:2012-09-23 修回日期:2012-11-04 发布日期:2012-11-05
通讯作者: 王锋鹏 E-mail:wfp@scu.edu.cn
基金资助:
国家自然科学基金(No. 30873147)和中国博士后科学基金(No. 2012M521670)资助项目.

Recent Progresses in the Synthesis of Taxol

Tang Pei^a,b, Wang Fengpeng^b

a Innovative Drug Research Centre, Bioengineering College, Chongqing University, Chongqing 401331;
b Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041

Received:2012-09-23 Revised:2012-11-04 Published:2012-11-05
Supported by:
Project supported by the National Natural Science Foundation of China (No. 30873147) and the China Postdoctoral Science Foundation (No. 2012M521670).

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摘要/Abstract

紫杉醇和多烯紫杉醇是目前销量最大的临床抗癌药物. 近年来围绕紫杉醇所进行的高水平研究仍然层出不穷. 综述了2008年以来紫杉醇的合成研究进展, 主要涉及紫杉醇6-8-6骨架的构建、环系的合成以及侧链的制备.

Taxol and docetaxel are currently the largest selling anticancer drugs. Numerous elegant studies about taxol and its analogues have been reported recently. In this review, the recent progresses in the synthesis of taxol are summarized. These examples cover the synthetic studies of the 6-8-6 tricyclic core, ring system, and side chain.

Key words: taxol, synthesis, progress

引用此文

唐培, 王锋鹏. 近年来紫杉醇的合成研究进展[J]. 有机化学, 2013, 33(03): 458-468.

Tang Pei, Wang Fengpeng. Recent Progresses in the Synthesis of Taxol[J]. Chin. J. Org. Chem., 2013, 33(03): 458-468.

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近年来紫杉醇的合成研究进展

Recent Progresses in the Synthesis of Taxol

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