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有机化学
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有机化学 ›› 2013, Vol. 33 ›› Issue (05): 905-914.DOI: 10.6023/cjoc2012010050 上一篇    下一篇

综述与进展

脂肪酶催化C—C键形成反应研究新进展

丁雁a, 黄和a,b, 胡燚a,b   

  1. a 南京工业大学生物与制药工程学院 南京 210009;
    b 材料化学工程国家重点实验室 南京 210009
  • 收稿日期:2012-10-28 修回日期:2012-12-13 发布日期:2013-01-04
  • 通讯作者: 胡燚,huyi@njut.edu.cn;025-58139942 E-mail:huyi@njut.edu.cn;025-58139942
  • 基金资助:

    国家自然科学重点基金(No. 20936002)、国家自然科学青年基金(No. 20906049)和国家高技术研究发展计划(863计划, No. 2011AA02A209)资助项目.

New Progress on Lipases Catalyzed C—C Bond Formation Reactions

Ding Yana, Huang Hea,b, Hu Yia,b   

  1. a College of Biotechnology and Pharmaceutical Engineering, Nanjing University of Technology, Nanjing 210009;
    b State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing 210009
  • Received:2012-10-28 Revised:2012-12-13 Published:2013-01-04
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 20936002), the National Natural Science Foundation of China for Yong Scholars (No. 20906049) and the National High Technology Research and Development Program (863 Program, No. 2011AA02A209).

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脂肪酶是一类重要的生物催化剂, 因其具有反应选择性高、条件温和、环境友好等特点, 被广泛应用于有机合成中. 综述了近年来脂肪酶催化Aldol缩合、Knoevenagel缩合、Michael加成、Henry反应等多种C—C键形成反应的新进展.

关键词: 脂肪酶, Aldol缩合, Knoevenagel缩合, C—C键形成

Lipases are the most widely used class of enzymes in organic synthesis due to their high selectivity, mild reaction conditions, environmental acceptability, etc. This article reviews the new progress on lipases catalyzed C—C bond formation reactions, such as aldol condensation, Knoevenagel condensation, Michael addition, Henry reaction, etc.

Key words: lipase, aldol condensation, Knoevenagel condensation, C—C bond formation