有机化学 ›› 2014, Vol. 34 ›› Issue (6): 1037-1047.DOI: 10.6023/cjoc201403006 上一篇    下一篇

研究专题

β-氧代酰胺衍生物的Vilsmeier反应在杂环化合物合成中的应用

梁永久a, 黄鹏a,b, 张睿a, 董德文a   

  1. a. 中国科学院长春应用化学研究所 长春 130022;
    b. 辽宁大学化学院 沈阳 110036
  • 收稿日期:2014-03-04 修回日期:2014-03-15 发布日期:2014-03-26
  • 通讯作者: 黄鹏, 董德文 E-mail:huangp019@126.com;dwdong@ciac.ac.cn
  • 基金资助:

    国家自然科学基金(Nos. 20872136,21172211)资助项目.

Vilsmeier Reactions of β-Oxo Amide Derivatives:Applications in the Synthesis of Heterocyclic Compounds

Liang Yongjiua, Huang Penga,b, Zhang Ruia, Dong Dewena   

  1. a. Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022;
    b. College of Chemistry, Liaoning University, Shenyang 110036
  • Received:2014-03-04 Revised:2014-03-15 Published:2014-03-26
  • Supported by:

    Project supported by the National Natural Science Foundation of China (Nos. 20872136, 21172211).

综述了我们研究组近几年在β-氧代酰胺化合物的Vilsmeier反应研究反面取得的进展. 设计、合成了系列具有多官能化结构特点的β-氧代酰胺化合物,对其Vilsmeier反应进行了系统研究,探讨了相关反应的机理,建立了基于β-氧代酰胺化合物Vilsmeier反应的四元、五元、六元杂环化合物的合成新方法.

关键词: β-氧代酰胺, Vilsmeier反应, 杂环化合物, 合成方法

Our recent research progress based on Vilsmeier reaction of β-oxo amide derivatives is summarized in this account. Series of functionalized β-oxo amide derivatives were designed and prepared, their reaction under the Vilsmeier reaction conditions and the mechanisms involved in these reactions were investigated. Efficient synthetic approaches for four-, five-, and six-membered heterocycles via Vilsmeier reaction of β-oxo amide derivatives had been developed.

Key words: β-oxo amides, Vilsmeier reaction, heterocycles, synthetic method