有机化学 ›› 2014, Vol. 34 ›› Issue (6): 1110-1117.DOI: 10.6023/cjoc201401042 上一篇    下一篇

研究论文

通过点击化学方法合成鹅去氧胆酸类分子钳及其识别性能研究

赵志刚, 王晓红, 石治川, 程玉宇   

  1. 西南民族大学化学与环境保护工程学院 成都 610041
  • 收稿日期:2014-01-25 修回日期:2014-03-10 发布日期:2014-04-15
  • 通讯作者: 赵志刚 E-mail:zzg63129@163.com
  • 基金资助:

    四川省科技支撑计划基金(No. 2012SZ0160)和国家外专局基金(No. 2013-32)资助项目.

Synthesis of Molecular Tweezers Derived from Chenodeoxycholic Acid through Click Reaction and Their Recogniton Properties

Zhao Zhigang, Wang Xiaohong, Shi Zhichuan, Cheng Yuyu   

  1. College of Chemistry and Environmental Protection Engineering, Southwest University for Nationalities, Chengdu 610041
  • Received:2014-01-25 Revised:2014-03-10 Published:2014-04-15
  • Supported by:

    Project supported by the Science and Technology Department of Sichuan Province (No. 2012SZ0160) and the National Foreign Expert Bureau (No. 2013-32).

通过点击化学方法设计合成了12个新型的含有1,2,3-三唑结构的鹅去氧胆酸类分子钳人工受体. 所有新目标物结构均经1H NMR,IR,MS及元素分析确证. 利用紫外可见光光度滴定法测试了主体化合物对阳离子的识别作用. 实验结果表明,主体分子对汞离子有良好的选择性识别性能.

关键词: 阳离子识别, 分子钳, 点击化学, 1,2,3-三唑, 鹅去氧胆酸

Twelve novel chenodeoxycholic acid-based molecular tweezer metal receptors containing 1,2,3-triazole moieties have been designed and synthesized using click chemistry method. The target compounds were characterized by 1H NMR, IR, MS spectra and elemental analysis. Their binding properties were examined by UV-Vis spectra titration. The results indicate that these molecular tweezers showed high selectivity and affinity for Hg2+ ion.

Key words: cation recognition, molecular tweezer, click chemistry, 1,2,3-triazole, chenodeoxycholic acid