有机化学 ›› 2016, Vol. 36 ›› Issue (11): 2583-2601.DOI: 10.6023/cjoc201603037 上一篇    下一篇

综述与进展

基于分子钳化合物的手性识别研究进展

刘贵君, 石浩   

  1. 浙江工业大学药学院 杭州 310014
  • 收稿日期:2016-03-23 修回日期:2016-06-19 发布日期:2016-07-08
  • 通讯作者: 石浩 E-mail:shihao@zjut.edu.cn
  • 基金资助:

    浙江省自然科学基金(No.LY13B020013)资助项目.

Progress in Chiral Recognition Based on Molecular Tweezers

Liu Guijun, Shi Hao   

  1. College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014
  • Received:2016-03-23 Revised:2016-06-19 Published:2016-07-08
  • Supported by:

    Project supported by the Natural Science Foundation of Zhejiang Province (No.LY13B020013).

手性是自然界中广泛存在的现象,设计合成新型人工受体模拟生物体内的分子识别已经成为生物有机化学和超分子化学等领域富于挑战性的课题之一.分子钳类人工受体结构易于修饰,在手性识别和检测中具有广泛的应用前景,本文对近年来合成的分子钳人工受体以及应用光谱、色谱和质谱等检测手段对其手性识别性能的研究进行了总结,并对分子钳人工受体的发展前景作出了展望.

关键词: 分子钳人工受体, 手性识别, 光谱, 色谱, 质谱

Chirality is a common phenomenon in nature. Designing and synthesis of novel artificial receptors to emulate the molecular recognition in living organism has become the challenging forefront of bioorganic chemistry and supramolecular chemistry. Molecular tweezers have been widely applied in chiral molecular recognition and detection for its easily modified structure. Molecular tweezers and their chiral recognition properties detected by spectrometry, chromatography and mass spectrometry are summarized in this paper, and the prospect of molecular tweezers is also discussed.

Key words: molecular tweezers artificial receptor, chiral recognition, spectrometry, chromatography, mass spectrometry