有机化学 ›› 2015, Vol. 35 ›› Issue (3): 570-577.DOI: 10.6023/cjoc201412048 上一篇    下一篇

综述与进展

过渡金属催化的C—H炔基化反应

王明明a, 王子潇b, 商明a, 戴辉雄a   

  1. a 中国科学院上海有机化学研究所 金属有机化学国家重点实验室 上海 200032;
    b 上海大学化学系 上海大学创新药物研究中心 上海 200444
  • 收稿日期:2014-12-29 修回日期:2015-01-26 发布日期:2015-01-28
  • 通讯作者: 戴辉雄 E-mail:hxdai@sioc.ac.cn
  • 基金资助:

    国家自然科学基金(No. 21472211)资助项目.

Transition-Metal-Catalyzed C—H Alkynylation

Wang Mingminga, Wang Zixiaob, Shang Minga, Dai Huixionga   

  1. a State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032;
    b Department of Chemistry, Innovative Drug Research Center, Shanghai University, Shanghai 200444
  • Received:2014-12-29 Revised:2015-01-26 Published:2015-01-28
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 21472211).

炔烃是药物和天然产物的重要骨架, 其合成一直受到有机化学家们的重视. 近年来, 过渡金属催化的惰性碳氢键炔基化作为一种重要的合成炔基化产物的方法, 受到了合成化学家的广泛关注. 总结了近10年来C(sp2)—H键和C(sp3)—H键炔基化反应的进展.

关键词: 炔基化, C—H键活化, 炔烃, 交叉脱氢偶联

Alkynyl compounds are paramount skeletons in pharmaceuticals and natural products, and great importance has been attached to its synthesis by organic chemists. Recently, transition-metal-catalyzed C—H alkynylation has attracted tremendous interest as a valuable tool for construction of alkynyl compounds. This review gives a summary of progress having been made in the field of the C(sp2)—H and C(sp3)—H alkynylation over the last ten years.

Key words: alkynylation, C—H activation, alkyne, cross dehydrogen coupling