苯并[b][1,4]二氮杂衍生物的合成及其应用新进展

doi:10.6023/cjoc201510002

摘要/Abstract

苯并[b][1,4]二氮杂衍生物是一类含有两个氮杂原子的苯并七元杂环化合物,以其特殊的结构特点和广泛的生理及药理活性而备受关注,因此其合成和活性研究也是有机化学及药学领域的研究热点.就近10年来苯并[b][1,4]二氮杂衍生物在抑菌、抗神经炎和抗癌活性等方面的应用进展进行了归纳总结;综述了其不同催化体系下合成及机理的最新研究进展,同时对本课题组的研究成果做了阐述,并对其合成及应用前景进行了展望.

关键词: 苯并[b][1,4]二氮杂, 合成, 应用, 催化剂, 研究进展

Benzo[b][1,4]diazepine derivatives is a class of benzo and seven-number heterocyclic compounds containing double nitrogen atoms. It was concerned for its special structural features, strong physiological and pharmacological activity. Therefore, the research on synthetic method and biological activity of benzo[b][1,4]diazepine has become one of the hot issues in the chemical and pharmaceutical areas. Their application in the antimicrobial, anti-neuroinflammatory, anticancer activity and so on in the recently ten years is reviewed. Besides, the progress in synthesis of the benzo[b][1,4]diazepine compounds at different types of catalysts and its synthetic reaction mechanisms are summarized. Meanwhile, the recent works of authors' research group are discussed. Their synthesis and application prospects are also expected.

Key words: benzo[b][1,4]diazepine, synthesis, application, catalyst, progress

引用此文

尹刘燕, 王兰芝, 李晓庆, 安迎双. 苯并[b][1,4]二氮杂衍生物的合成及其应用新进展[J]. 有机化学, 2016, 36(4): 711-723.

Yin Liuyan, Wang Lanzhi, Li Xiaoqing, An Yingshuang. Progress in Synthesis and Application of Benzo[b][1,4]diazepine Derivatives[J]. Chin. J. Org. Chem., 2016, 36(4): 711-723.

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