有机化学 ›› 2017, Vol. 37 ›› Issue (4): 1016-1019.DOI: 10.6023/cjoc201611021 上一篇    下一篇

研究简报

全叶马兰中两个新的黄酮类化合物

王国凯a, 孙云鹏a, 王诤a, 张楠a, 王刚a, 周忠玉b, 刘劲松a   

  1. a. 安徽中医药大学药学院 现代中药安徽省重点实验室 合肥 230012;
    b. 中国科学院华南植物园 广东省应用植物学重点实验室 广州 510650
  • 收稿日期:2016-11-18 修回日期:2016-12-13 发布日期:2017-01-17
  • 通讯作者: 王刚, 刘劲松 E-mail:jinsongliu108@sina.com;kunhong_8@163.com
  • 基金资助:

    国家自然科学基金(No.81303220)、安徽省自然科学基金(No.11040606M220)和中国科学院华南植物园广东应用植物重点实验室(No.AB2015001)资助项目.

Two New Flavonoids from Kalimeris integrifolia

Wang Guokaia, Sun Yunpenga, Wang Zhenga, Zhang Nana, Wang Ganga, Zhou Zhongyub, Liu Jinsonga   

  1. a. Anhui Key Laboratory for mordern Chinese Materia Medica, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230012;
    b. Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650
  • Received:2016-11-18 Revised:2016-12-13 Published:2017-01-17
  • Contact: 10.6023/cjoc201611021 E-mail:jinsongliu108@sina.com;kunhong_8@163.com
  • Supported by:

    Project supported by the National Natural Science Foundation of China (No. 81303220), the Natural Sciences Foundation of Anhui Province (No. 11040606M220) and the Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, CAS (No. AB2015001).

利用多种色谱分离方法对全叶马兰(Kalimeris integrifolia)的化学成分进行研究,从其地上部分的乙醇提取物中分离得到两个化合物,应用HR-ESIMS,1D 和2D NMR,IR,UV等多种波谱技术确定了化合物的化学结构,经鉴定分别为5,8-二羟基-2-(3-羟基-4,5-二甲氧苯基)-6,7-二甲氧基-4H-色烯-4-酮(1)和5-羟基-6,7-二甲氧基-2-(4'-甲氧基苯基)-4-氧代-4H-色烯-8-(2''-甲基丁酸酯) (2). 化合物12为两个新的黄酮类化合物.

关键词: 全叶马兰, 菊科, 化学成分, 黄酮类

Investigation on Kalimeris integrifolia resulted in two compounds by means of various chromatographic techniques (silica gel, Sephadex LH-20, RP-LC and Pre-HPLC). Their structures were determined as 5,8-dihydroxy-2-(3-hydroxy- 4,5-dimethoxyphenyl)-6,7-dimethoxy-4H-chromen-4-one (1) and 5-hydroxy-6,7-dimethoxy-2-(4-methoxyphenyl)-4-oxo-4H- chromen-8-yl 2-methylbutanoate (2) on the basis of extensive spectroscopic analyses including MS, IR, UV, 1D- and 2D- NMR. Among them, compounds 1 and 2 are two new flavonoids, named as kalinturflavone A (1) and kalinturflavone B (2).

Key words: Kalimeris integrifolia, Asteraceae, chemical constituent, flavonoids