海洋天然产物呋喃二倍半萜(18S)-variabilin的全合成

doi:10.6023/cjoc201702007

有机化学 ›› 2017, Vol. 37 ›› Issue (8): 2101-2108.DOI: 10.6023/cjoc201702007 上一篇下一篇

研究论文

海洋天然产物呋喃二倍半萜(18S)-variabilin的全合成

熊维艳^a, 赵迎春^a, 徐亮^a, 季红^b

a 四川大学华西药学院天然药物系暨教育部靶向药物重点实验室成都 610041;
b 广州医科大学药学院广州 511436

收稿日期:2017-02-08 修回日期:2017-03-13 发布日期:2017-04-01
通讯作者: 徐亮, 季红 E-mail:liangxu@scu.edu.cn;dljih@126.com
基金资助:
国家自然科学基金（Nos.21472129，21272163）资助项目.

Total Synthesis of Marine Furanosesterterpene Natural Product, (18S)-Variabilin

Xiong Weiyan^a, Zhao Yingchun^a, Xu Liang^a, Ji Hong^b

a Key Laboratory of Drug Targeting of Ministry of Education, and Department of Chemistry of Medicinal Natural Products, West China College of Pharmacy, Sichuan University, Chengdu 610041;
b School of Pharmaceutical Science, Guangzhou Medical University, Guangzhou 511436

Received:2017-02-08 Revised:2017-03-13 Published:2017-04-01
Contact: 10.6023/cjoc201702007 E-mail:liangxu@scu.edu.cn;dljih@126.com
Supported by:
Project supported by the National Natural Science Foundation of China (Nos. 21472129, 21272163).

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摘要/Abstract

（18S）-variabilin是代表性的呋喃二倍半萜海洋天然产物，具有广泛的生物活性.以香叶醇为起始原料，在通过Evans不对称烷基化反应构建关键手性片段的基础上，经关键的Julia-Lythgoe偶联反应和Aldol类型缩合反应，以13步的最长线性步骤完成了（18S）-variabilin的合成.

关键词: variabilin, 呋喃二倍半萜, 不对称全合成

(18S)-Variabilin is the representative furanosesterterpenes, which exhibits varieties of bioactivities. Starting from geraniol and the key chiral segment prepared via Evans' asymmetric alkylation protocol, (18S)-variabilin has been totally synthesized in the longest linear 13 steps involving Julia-Lythgoe coupling reaction and aldol-type condensation.

Key words: variabilin, furanosesterterpenes, asymmetric total synthesis

引用此文

熊维艳, 赵迎春, 徐亮, 季红. 海洋天然产物呋喃二倍半萜(18S)-variabilin的全合成[J]. 有机化学, 2017, 37(8): 2101-2108.

Xiong Weiyan, Zhao Yingchun, Xu Liang, Ji Hong. Total Synthesis of Marine Furanosesterterpene Natural Product, (18S)-Variabilin[J]. Chin. J. Org. Chem., 2017, 37(8): 2101-2108.

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海洋天然产物呋喃二倍半萜(18S)-variabilin的全合成

Total Synthesis of Marine Furanosesterterpene Natural Product, (18S)-Variabilin

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