有机化学 ›› 2021, Vol. 41 ›› Issue (3): 1251-1254.DOI: 10.6023/cjoc202009038 上一篇    下一篇

研究简报

Penicillium herquei JX4活性次级代谢产物研究

吴习斌a,c, 谭银丰b, 易继凌a,c, 宋鑫明a,c, 杨静雨a,c, 周学明a,c,*(), 陈光英a,c,*()   

  1. a 海南师范大学化学与化工学院 热带药用资源化学教育部重点实验室 海口 571158
    b 海南医学院 海南省热带药用植物研究开发重点实验室 海口 570216
    c 海南师范大学化学与化工学院 热带药用植物化学海南省重点实验室 海口 571158
  • 收稿日期:2020-09-16 修回日期:2020-10-14 发布日期:2020-11-04
  • 通讯作者: 周学明, 陈光英
  • 基金资助:
    海南省自然科学基金(218QN234); 海南省热带药用植物研究开发重点实验室开放研究项目(KF202003); 国家自然科学基金(21662012); 国家自然科学基金(41866005); 以及教育部创新研究团队(IRT-16R19)

Study on Bioactive Secondary Metabolites from Penicillium herquei JX4

Xibin Wua,c, Yinfeng Tanb, Jiling Yia,c, Xinming Songa,c, Jingyu Yanga,c, Xueming Zhoua,c,*(), Guangying Chena,c,*()   

  1. a Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
    b Hainan Provincial Key Laboratory of R&D on Tropical Herbs, Hainan Medical College, Haikou 570216
    c Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158
  • Received:2020-09-16 Revised:2020-10-14 Published:2020-11-04
  • Contact: Xueming Zhou, Guangying Chen
  • About author:
    * Corresponding authors. E-mail: ;
  • Supported by:
    Natural Science Foundation of Hainan Province(218QN234); Open Research Projects of Hainan Provincial Key Laboratory of Research and Development on Tropical Herbs(KF202003); National Natural Science Foundation of China(21662012); National Natural Science Foundation of China(41866005); Innovative Research Team Project of Ministry(IRT-16R19)

从红树角果木内生真菌Penicillium herqueiJX4中分离纯化得到11个次级代谢产物, 应用质谱(MS)、核磁共振(NMR)以及圆二色谱(ECD)等多种波谱和光谱技术确定了11个次级代谢产物的结构, 经鉴定分别为Penicillquei A (1), Penicillquei B (2), Pyrophen (3), Alaromydien A (4), Penicillar E (5), Aculene D (6), Sordaricin (7), BE-31405 (8), Vermistatin (9), Aspergillumarin A (10)和Aspergillumarin B (11). 化合物12新化合物. 抑菌活性测试表明化合物2, 3, 78具有广谱的抗植物病原菌活性.

关键词: 青霉属真菌, 次级代谢产物, 抗植物病原菌活性

Two new secondary metabolites, penicillqueies A and B (1and2), together with penicillquei A (1), penicillquei B (2), pyrophen (3), alaromydien A (4), penicillar E (5), aculene D (6), sordaricin (7), BE-31405 (8), vermistatin (9), aspergillumarin A (10) and aspergillumarin B (11) were isolated from Penicillium herqueiJX4. Their structures were elucidated using comprehensive spectroscopic methods. The absolute configuration of penicillquei A was determined by its experimental and calculated electronic circular dichroism (ECD) spectra. Compounds 2,3, 7 and 8 showed broad spectrum antifungal activities against nine phytopathogenic fungi.

Key words: Penicillium herquei, secondary metabolites, antifungal activity