五倍子中一个新的甘遂烷型三萜类化合物

doi:10.6023/cjoc202012045

有机化学 ›› 2021, Vol. 41 ›› Issue (6): 2511-2514.DOI: 10.6023/cjoc202012045 上一篇下一篇

研究简报

五倍子中一个新的甘遂烷型三萜类化合物

李钰婷, 仝雪利, 田立文^*()

南方医科大学药学院广州 510515

收稿日期:2020-12-27 修回日期:2021-01-28 发布日期:2021-02-26
通讯作者: 田立文
基金资助:
国家自然科学基金(81703381)

A New Tirucallane Triterpenoid from Galla chinensis

Yuting Li, Xueli Tong, Liwen Tian()

School of Pharmaceutical Sciences, Southern Medical University, Guangzhou 510515

Received:2020-12-27 Revised:2021-01-28 Published:2021-02-26
Contact: Liwen Tian
Supported by:
National Natural Science Foundation of China(81703381)

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摘要/Abstract

从五倍子的乙酸乙酯提取物中分离得到一个新的甘遂烷型三萜和五个已知的甘遂烷型三萜. 化合物的结构通过多种波谱分析技术得到鉴定. 这是首次从五倍子中分离得到三萜类化合物. 其中, 乳香二烯酮酸(3)、异乳酸二烯酮(4)和masticadienolic acid (5)在浓度为1.6 μmol•L ^–1时显示出神经保护活性, 该研究为发现神经保护药物提供了一个结构模板.

关键词: 五倍子, 甘遂烷型三萜, 神经保护活性

A new tirucallane triterpenoid was isolated from the ethyl acetate extract of Galla chinensis, along with five known tirucallane triterpenoids. Their structures were elucidated by extensive spectrosopic data analysis. It is the first time to report triterpenoids from G. chinensis. Masticadienonic acid (3), isomasticadienonic acid (4) and masticadienolic acid (5) showed neuroprotective activity at a concentration of 1.6 μmol•L ^–1. This study provides a structure template for neuroprotection agent discovery.

Key words: Galla chinensis, tirucallane triterpenoid, neuroprotective activity

引用此文

李钰婷, 仝雪利, 田立文. 五倍子中一个新的甘遂烷型三萜类化合物[J]. 有机化学, 2021, 41(6): 2511-2514.

Yuting Li, Xueli Tong, Liwen Tian. A New Tirucallane Triterpenoid from Galla chinensis[J]. Chinese Journal of Organic Chemistry, 2021, 41(6): 2511-2514.

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参考文献 17

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No.	δ_H (J in Hz)^a	δ_C^b	No.	δ_H (J in Hz)^a	δ_C^b
1α	1.69~1.76 (m, 1H)	39.8 (t)	16α	1.96~2.04 (m, 1H)	28.1 (t)
1β	2.50~2.61 (m, 1H)		16β	1.29~1.37 (m, 1H)
2α	2.27 (dd, 14.5, 3.2, 1H)	35.2 (t)	17	1.44~1.56 (m, 1H)	52.7 (d)
2β	2.80 (dd, 14.5, 4.7, 1H)		18	0.92 (s, 3H)	21.5 (q)
3		216.8 (s)	19	1.13 (s, 3H)	13.7 (q)
4		48.3 (s)	20	1.41~1.47 (m, 1H)	36.2 (d)
5	1.79 (dd, 10.4, 6.9, 1H)	52.7 (d)	21	0.93 (d, 6.6, 3H)	18.4 (q)
6α	1.69~1.76 (m, 1H)	24.7 (t)	22a	1.47~1.59 (m, 1H)	35.7 (t)
6β	2.50~2.61 (m, 1H)		22b	1.11~1.19 (m, 1H)
7	5.40 (brs, 1H)	119.9 (d)	23a	2.52~2.64 (m, 1H)	27.0 (t)
8		141.3 (s)	23b	2.41~2.50 (m, 1H)
9	2.34 (d, 10.3, 1H)	56.5 (d)	24	6.10 (t, 7.6, 1H)	146.1 (d)
10		36.7 (s)	25		125.9 (s)
11	4.21~4.27 (m, 1H)	67.6 (d)	26		171.6 (s)
12α	1.69~1.76 (m, 1H)	48.7 (t)	27	1.94 (s, 3H)	20.7 (q)
12β	2.50~2.61 (m, 1H)		28	1.08 (s, 3H)	24.6 (q)
13		44.3 (s)	29	1.14 (s, 3H)	21.9 (q)
14		51.2 (s)	30	0.94 (s, 3H)	27.9 (q)
15	1.47~1.60 (m, 2H)	34.4 (t)

No.	δ_H (J in Hz)^a	δ_C^b	No.	δ_H (J in Hz)^a	δ_C^b
1α	1.69~1.76 (m, 1H)	39.8 (t)	16α	1.96~2.04 (m, 1H)	28.1 (t)
1β	2.50~2.61 (m, 1H)		16β	1.29~1.37 (m, 1H)
2α	2.27 (dd, 14.5, 3.2, 1H)	35.2 (t)	17	1.44~1.56 (m, 1H)	52.7 (d)
2β	2.80 (dd, 14.5, 4.7, 1H)		18	0.92 (s, 3H)	21.5 (q)
3		216.8 (s)	19	1.13 (s, 3H)	13.7 (q)
4		48.3 (s)	20	1.41~1.47 (m, 1H)	36.2 (d)
5	1.79 (dd, 10.4, 6.9, 1H)	52.7 (d)	21	0.93 (d, 6.6, 3H)	18.4 (q)
6α	1.69~1.76 (m, 1H)	24.7 (t)	22a	1.47~1.59 (m, 1H)	35.7 (t)
6β	2.50~2.61 (m, 1H)		22b	1.11~1.19 (m, 1H)
7	5.40 (brs, 1H)	119.9 (d)	23a	2.52~2.64 (m, 1H)	27.0 (t)
8		141.3 (s)	23b	2.41~2.50 (m, 1H)
9	2.34 (d, 10.3, 1H)	56.5 (d)	24	6.10 (t, 7.6, 1H)	146.1 (d)
10		36.7 (s)	25		125.9 (s)
11	4.21~4.27 (m, 1H)	67.6 (d)	26		171.6 (s)
12α	1.69~1.76 (m, 1H)	48.7 (t)	27	1.94 (s, 3H)	20.7 (q)
12β	2.50~2.61 (m, 1H)		28	1.08 (s, 3H)	24.6 (q)
13		44.3 (s)	29	1.14 (s, 3H)	21.9 (q)
14		51.2 (s)	30	0.94 (s, 3H)	27.9 (q)
15	1.47~1.60 (m, 2H)	34.4 (t)

五倍子中一个新的甘遂烷型三萜类化合物

A New Tirucallane Triterpenoid from Galla chinensis

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