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有机化学
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有机化学 ›› 2004, Vol. 24 ›› Issue (1): 63-66. 上一篇    下一篇

研究论文

应用Arndt-Eistert 反应合成手性非天然N-Fmoc-β-氨基酸(III)

廖本仁*,a, 洪镛裕b, 徐军a, 刘波b   

  1. a上海化学试剂研究所 上海 200333;
    b华东师范大学化学系 上海 200062
  • 收稿日期:2003-01-22 修回日期:2003-06-19 接受日期:2003-08-10 发布日期:2022-09-21

Synthesis of Chiral Unnatural N-Fmoc-β-homoamino Acids(III) via Arndt-Eistert Reaction

LIAO Ben-Ren*,a, HONG Yong-Yub, XU Juna, LIU Bob   

  1. aShanghai Institute of Chemical Reagent, Shanghai 200333;
    bDepartment of Chemistry, East China Normal University, Shanghai 200062
  • Received:2003-01-22 Revised:2003-06-19 Accepted:2003-08-10 Published:2022-09-21
  • Contact: *E-mail: liaobenren@163.com; Fax: 021-62848204

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以重氮甲烷为重氮化试剂,以非天然N-Fmoc-α-氨基酸为原料,成功地运用Arndt-Eistert 反应,通过两步反应,高效快捷地合成了8个对应的同系物N-Fmoc-β-氨基酸.

关键词: Arndt-Eistert 合成, N-Fmoc-非天然α-氨基酸, 重氮甲烷, 重氮甲酮, N-Fmoc-β-氨基酸

The synthesis of eight optical pure N-Fmoc-β-amino acids from the unnatural chiral N-Fmoc-α-amino acids by Arndt-Eistert reaction was accomplished with high yields in only two steps.

Key words: Arndt-Eistert, unnatural N-Fmoc-α-amino acid, diazomethane, diazoketone, N-Fmoc-β-amino acid