硼-10富集硼烷Lewis碱加合物的合成

doi:10.6023/cjoc202302032

有机化学 ›› 2023, Vol. 43 ›› Issue (5): 1772-1776.DOI: 10.6023/cjoc202302032 上一篇下一篇

所属专题：有机硼化学专辑

研究论文

硼-10富集硼烷Lewis碱加合物的合成

梁沙沙^a, 马艳娜^a^,^*(), 陈学年^a^,^b^,^*()

a 郑州大学化学学院郑州 450001
b 河南师范大学化学化工学院河南新乡 453007

收稿日期:2023-02-28 修回日期:2023-04-25 发布日期:2023-04-26
通讯作者: 马艳娜, 陈学年
基金资助:
国家自然科学基金(22171246); 国家自然科学基金(22271256)

Synthesis of ¹⁰B-Enriched Borane Lewis Base Adducts

Shasha Liang^a, Yanna Ma^a(), Xuenian Chen^a^,^b()

a College of Chemistry, Zhengzhou University, Zhengzhou 450001
b School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007

Received:2023-02-28 Revised:2023-04-25 Published:2023-04-26
Contact: Yanna Ma, Xuenian Chen
Supported by:
National Natural Science Foundation of China(22171246); National Natural Science Foundation of China(22271256)

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摘要/Abstract

天然硼中主要含有两种稳定同位素, 即硼-10和硼-11, 丰度分别为19.78%和80.22%. 其中, 富集的硼-10同位素在核工业以及放射治疗癌症等方面有重要应用. 因此, 硼-10富集含硼化合物的合成具有重要的研究意义. 硼烷类化合物是合成这类化合物的主要起始原料, 但是目前合成硼-10富集硼烷化合物的方法还比较少. 以商业可得的硼-10富集硼酸为起始原料, 首先采用改进的文献方法合成了硼-10富集的Na¹⁰BH₄, Na¹⁰BH₄与碘单质反应生成乙硼烷(¹⁰B₂H₆), 然后, 乙硼烷与各种Lewis碱进行配位, 得到了一系列硼-10富集的硼烷Lewis碱加合物, 包括四氢呋喃硼烷(THF•¹⁰BH₃)、二甲基硫醚硼烷(DMS•¹⁰BH₃)、N,N-二甲基苯胺硼烷(DMA•¹⁰BH₃)、氨硼烷(NH₃•¹⁰BH₃)、三甲胺硼烷(Me₃N•¹⁰BH₃)、三苯基磷硼烷(Ph₃P•¹⁰BH₃)和N-杂环卡宾硼烷[IPr•¹⁰BH₃, IPr=1,3-双(2,6-二异丙基苯基)咪唑-2-亚基]. 该方法操作简单, 反应收率高, 为硼-10富集化合物的合成提供了物质基础.

关键词: 硼-10富集同位素, ¹⁰B(OH)₃, Na¹⁰BH₄, L•¹⁰BH₃

In nature, boron is composed of a mixture of two stable isotopes, ¹⁰B (19.78%) and ¹¹B (80.22%). The isotopical ¹⁰B-enriched compounds play important roles in many fields, such as the nuclear industry and cancer radiate treatment. Therefore, the syntheses of such kind of compounds is of important significance. These isotopical ¹⁰B-enriched compounds can be prepared from ¹⁰B-enriched boranes, however, the synthetic methods of such boranes are few. Herein, the synthetic methods of ¹⁰B-enriched Na¹⁰BH₄, THF•¹⁰BH₃, DMS•¹⁰BH₃, DMA•¹⁰BH₃, NH₃•¹⁰BH₃, Me₃N•¹⁰BH₃, Ph₃P•¹⁰BH₃, and IPr•¹⁰BH₃ were developed. Firstly, Na¹⁰BH₄ was synthesized with commercially available ¹⁰B(OH)₃ as starting material based on the modified literature methods. Then the reaction of Na¹⁰BH₄ and I₂ provided ¹⁰B₂H₆, which could rapidly react with different Lewis bases to afford corresponding L•¹⁰BH₃. Undoubtedly, these approaches provide convenient ways for the synthesis of ¹⁰B-enriched compounds.

Key words: ¹⁰B-enriched isotope, ¹⁰B(OH)₃, Na¹⁰BH₄, L•¹⁰BH₃

引用此文

梁沙沙, 马艳娜, 陈学年. 硼-10富集硼烷Lewis碱加合物的合成[J]. 有机化学, 2023, 43(5): 1772-1776.

Shasha Liang, Yanna Ma, Xuenian Chen. Synthesis of ¹⁰B-Enriched Borane Lewis Base Adducts[J]. Chinese Journal of Organic Chemistry, 2023, 43(5): 1772-1776.

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图/表 4

图式1. Na10BH4和Lewis碱硼烷加合物L?10BH3的合成

Scheme 1. Synthesis of Na10BH4 and borane lewis base adducts L?10BH3

图式2. Na10BH4的合成

Scheme 2. Synthesis of Na10BH4

图1. Na10BH4 (10B含量为99%)的1H NMR谱

Figure 1. 1H NMR spectrum of Na10BH4 (the content of 10B is 99%)

图2. Na10BH4 (10B含量为99%)的10B NMR谱

Figure 2. 10B NMR spectrum of Na10BH4 (the content of 10B is 99%)

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硼-10富集硼烷Lewis碱加合物的合成

Synthesis of ¹⁰B-Enriched Borane Lewis Base Adducts

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硼-10富集硼烷Lewis碱加合物的合成

Synthesis of 10B-Enriched Borane Lewis Base Adducts

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Synthesis of ¹⁰B-Enriched Borane Lewis Base Adducts